Abstract
The healing of full thickness excised wounds of pig skin was studied by quantitative polarized light microscopy. Newly formed collagen was only faintly acidophilic and birefringent. Acidophilia and birefringence increased with age. Intrinsic birefringence was almost zero in young collagen and even after 56 days it was much below that of pre-existing collagen. Form birefringence behaved similarly. The findings indicate that maturation of collagen involves more nearly parallel alignment of molecules, presumably through cross-linking involving mainly anionic groups. Peculiar and improperly understood changes in the collagen of autografts are described.
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Selected References
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- ADAMS C. W., TUQAN N. A. Elastic degeneration as source of lipids in the early lesion of atherosclerosis. J Pathol Bacteriol. 1961 Jul;82:131–139. doi: 10.1002/path.1700820116. [DOI] [PubMed] [Google Scholar]
- Carlson L., Neumark T., Magony I. Connection between structure and dry mass concentration of collagen fibre. I. Alteration in dry mass concentration of collagen fibres during aeging. Acta Histochem. 1970;35(2):320–323. [PubMed] [Google Scholar]
- Constantine V. S., Mowry R. W. Selective staining of human dermal collagen. I. An analysis of standard methods. J Invest Dermatol. 1968 May;50(5):414–418. doi: 10.1038/jid.1968.67. [DOI] [PubMed] [Google Scholar]
- Douglas D. M., Forester J. C., Ogilvie R. R. Physical characteristics of collagen in the later stages of wound healing. Br J Surg. 1969 Mar;56(3):219–222. doi: 10.1002/bjs.1800560316. [DOI] [PubMed] [Google Scholar]
- Elden H. R. Physical properties of collagen fibers. Int Rev Connect Tissue Res. 1968;4:283–348. doi: 10.1016/b978-1-4831-6754-1.50013-3. [DOI] [PubMed] [Google Scholar]
- Ordman L. J., Gillman T. Studies in the healing of cutaneous wounds. I. The healing of incisions through the skin of pigs. Arch Surg. 1966 Dec;93(6):857–882. doi: 10.1001/archsurg.1966.01330060001001. [DOI] [PubMed] [Google Scholar]
- VERZAR F., WILLENEGGER H. [Aging of the collagen in skin and scars]. Schweiz Med Wochenschr. 1961 Oct 14;91:1234–1236. [PubMed] [Google Scholar]
- Wolman M. On the use of polarized light in pathology. Pathol Annu. 1970;5:381–416. [PubMed] [Google Scholar]