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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1974 Jun;55(3):275–281.

Ultrastructural Changes in Lung Fibroblast Cultures Exposed to Chrysotile Asbestos

R J Richards, P M Hext, G Blundell, W J Henderson, B E Volcani
PMCID: PMC2072625  PMID: 4472518

Abstract

Early changes in the ultrastructure of lung fibroblasts exposed to chrysotile asbestos in vitro are described. The dust exposed cells rapidly undergo a “maturation process” reflected by highly dilated endoplasmic cisternae, irregularity in nuclear outline and composition and the appearance of membrane microvilli which are all characteristics of normal cells in the stationary phase. It is suggested the surviving cells undergoing this “maturation process” may account in part for the higher synthetic activity, leading to increased collagen levels, in chrysotile exposed cultures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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