Skip to main content
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1974 Feb;55(1):38–46.

Increased Phagocytic Cell Activity and Anaemia in Corynebacterium parvum Treated Mice

W H McBride, J T Jones, D M Weir
PMCID: PMC2072669  PMID: 4835797

Abstract

The injection of C. parvum into CBA mice causes marked changes in the lymphoid tissues including enlargement of the splenic white and red pulp, trapping of red cells, proliferation of phagocytic cells and increased rate of clearance of carbon and bovine albumin. Associated with these changes is a transient anaemia. Evidence for increased phagocytosis of syngeneic red cells and autoantibody formation against red cells in C. parvum treated mice is presented. The inter-relationship of these phenomena and the role of C. parvum in their induction are discussed.

Full text

PDF
38

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chen L. T., Weiss L. The role of the sinus wall in the passage of erythrocytes through the spleen. Blood. 1973 Apr;41(4):529–537. [PubMed] [Google Scholar]
  2. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  3. Halpern B., Fray A. Déclenchement de l'anémie hémolytique autoimmune chez de jeunes souriceaux NZB par l'administration de Corynebacterium parvum. Ann Inst Pasteur (Paris) 1969 Dec;117(6):778–789. [PubMed] [Google Scholar]
  4. Holm G., Hammarström S. Haemolytic activity of human blood monocytes. Lysis of human erythrocytes treated with anti-A serum. Clin Exp Immunol. 1973 Jan;13(1):29–43. [PMC free article] [PubMed] [Google Scholar]
  5. JANDL J. H., FILES N. M., BARNETT S. B., MACDONALD R. A. PROLIFERATIVE RESPONSE OF THE SPLEEN AND LIVER TO HEMOLYSIS. J Exp Med. 1965 Aug 1;122:299–326. doi: 10.1084/jem.122.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. McCracken A., McBride W. H., Weir D. M. Adjuvant-induced antired blood cell activity in CBA mice. Clin Exp Immunol. 1971 Jun;8(6):949–955. [PMC free article] [PubMed] [Google Scholar]
  7. PREVOT A. R., TRANVANPHI J. ETUDE COMPARATIVE DE LA STIMULATION DU SYST'EME R'ETICULOENDOTH'ELIAL PAR DIFF'ERENTES SOUCHES DE CORYNEBACT'ERIES ANA'EROBIES EL D'ESP'ECES. C R Hebd Seances Acad Sci. 1964 May 4;258:4619–4621. [PubMed] [Google Scholar]
  8. Pinckard R. N., Weir D. M., McBride W. H. Factors influencing the immune response. 3. The blocking effect of Corynebacterium parvum upon the induction of acquired immunological unresponsiveness to bovine serum albumin in the adult rabbit. Clin Exp Immunol. 1968 Jun;3(5):413–421. [PMC free article] [PubMed] [Google Scholar]
  9. Pinckard R. N., Weir D. M., McBride W. H. Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits. Clin Exp Immunol. 1967 May;2(3):331–341. [PMC free article] [PubMed] [Google Scholar]
  10. Plotz P. H., Talal N. Fractionation of splenic antibody-forming cells on glass bead columns. J Immunol. 1967 Dec;99(6):1236–1242. [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES