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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1975 Jun;56(3):256–264.

In vivo microscopic observations of the pathogenesis of acute mouse viral hepatitis.

E H Bloch, K S Warren, M S Rosenthal
PMCID: PMC2072702  PMID: 172100

Abstract

In vivo microscopy of the liver was undertaken to determine the extent of involvement of the hepatic microvascular system in mice infected with viral hepatitis (MHV-3). It was found that the major effects of the disease were produced in localized areas where parenchyma, sinusoids and blood were obliterated. However, immediately peripheral to these lesions blood flow and vessels were unaffected other than by localized hypertrophy of Küpffer cells. While each lesion produced a sinusoidal block to blood flow, portal hypertension did not occur even in the presence of extensive focal and confluent necrosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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