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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1974 Dec;55(6):583–588.

The Different Susceptiblility of Rat Liver Lobes to Carbon Tetrachloride and Dimethylnitrosamine

T A Lawson, A W Pound
PMCID: PMC2072722  PMID: 4447792

Abstract

The extent of liver damage in rats dosed with carbon tetrachloride (CCl4) or dimethylnitrosamine (DMN), by intragastric or intraperitoneal injection, has been compared in the different lobes. The level of activity of DMN-demethylase in the lobes has also been measured as an index of the activity of the microsomal enzymes. DMN-demethylase activity was greater in the left and left median lobes than in the right and right median lobes. The extent of liver damage (disruption of the basophilic bodies and necrosis) was greater in the right than in the left lobes of animals dosed with CCl4 but was greater in the left lobes of animals given DMN. The route of injection made no difference. The distribution of liver damage may be explained by the distribution of microsomal enzymes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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