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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1975 Apr;56(2):183–192.

Haematological changes and iron metabolism in rats after administration of Corynebacterium parvum.

B Brozovic, V S Sljivić, G W Warr
PMCID: PMC2072739  PMID: 1203175

Abstract

Administration of 1-4 mg of C. parvum to rats caused a transient and mild normochromic and normocytic anaemia with reticulocytosis. There was also an immediate and marked fall of plasma iron concentration and a moderate increase of total iron binding capacity of plasma. Despite increased clearance of 59Fe from the plasma there was no significant change of the plasma iron turnover rate. At later intervals after administration of C. parvum an increased incorporation of iron into red blood cells and the spleen was observed. These changes in iron metabolism have been explained in terms of increased retention of iron in the mononuclear phagocyte system during the first few days after C. parvum and enhanced erythropoiesis at later intervals. Other haematological parameters remained normal, with the exception of the absolute number of lymphocytes, which initially fell sharply but soon returned to, and even exceeded, control levels. Liver and spleen weights increased greatly after administration of C. parvum, reaching a maximum at the end of the first week, and both these organs contained mononuclear cell infiltrates, granulomata and giant cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlam C., Scott M. T. Lympho-reticular stimulatory properties of Corynebacterium parvum and related bacteria. J Med Microbiol. 1973 Aug;6(3):261–274. doi: 10.1099/00222615-6-3-261. [DOI] [PubMed] [Google Scholar]
  2. Boak J. L., Christie G. H., Ford W. L., Howard J. G. Pathways in the development of liver macrophages: alternative precursors contained in populations of lymphocytes and bone-marrow cells. Proc R Soc Lond B Biol Sci. 1968 Feb 27;169(1016):307–327. doi: 10.1098/rspb.1968.0013. [DOI] [PubMed] [Google Scholar]
  3. Cartwright G. E., Lee G. R. The anaemia of chronic disorders. Br J Haematol. 1971 Aug;21(2):147–152. doi: 10.1111/j.1365-2141.1971.tb03424.x. [DOI] [PubMed] [Google Scholar]
  4. Dazord L., Toujas L., Ramee M. P., Guelfi J. Prolifération dans la rate de cellules dérivées de la moelle osseuse après injection de bactéries immunostimulantes. Ann Immunol (Paris) 1973 Aug;124(3):375–381. [PubMed] [Google Scholar]
  5. FREIREICH E. J., MILLER A., EMERSON C. P., ROSS J. F. The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production. Blood. 1957 Nov;12(11):972–983. [PubMed] [Google Scholar]
  6. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  7. Halpern B., Fray A. Déclenchement de l'anémie hémolytique autoimmune chez de jeunes souriceaux NZB par l'administration de Corynebacterium parvum. Ann Inst Pasteur (Paris) 1969 Dec;117(6):778–789. [PubMed] [Google Scholar]
  8. Lukens J. N., Cartwright G. E., Wintrobe M. M. Anemia of adjuvant-induced inflammation in rats. Proc Soc Exp Biol Med. 1967 Nov;126(2):346–349. doi: 10.3181/00379727-126-32441. [DOI] [PubMed] [Google Scholar]
  9. Lukens J. N. Control of erythropoiesis in rats with adjuvant-induced chronic inflammation. Blood. 1973 Jan;41(1):37–44. [PubMed] [Google Scholar]
  10. McBride W. H., Jones J. T., Weir D. M. Increased phagocytic cell activity and anaemia in Corynebacterium parvum treated mice. Br J Exp Pathol. 1974 Feb;55(1):38–46. [PMC free article] [PubMed] [Google Scholar]
  11. McCracken A., McBride W. H., Weir D. M. Adjuvant-induced antired blood cell activity in CBA mice. Clin Exp Immunol. 1971 Jun;8(6):949–955. [PMC free article] [PubMed] [Google Scholar]
  12. Mikolajew M., Kuratowska Z., Kossakowska M., Plachecka M., Kopeć M. Haematological changes in adjuvant disease in the rat. II. Iron metabolism and 51Cr erythrocyte survival. Ann Rheum Dis. 1969 Mar;28(2):172–179. doi: 10.1136/ard.28.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scott M. T. Depression of delayed-type hypersensitivity by Corynebacterium parvum: mandatory role of the spleen. Cell Immunol. 1974 Aug;13(2):251–263. doi: 10.1016/0008-8749(74)90243-3. [DOI] [PubMed] [Google Scholar]
  14. Smith S. E., Scott M. T. Biological effects of Corynebacterium parvum. 3. Amplification of resistance and impairment of active immunity to murine tumours. Br J Cancer. 1972 Oct;26(5):361–367. doi: 10.1038/bjc.1972.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Warr G. W., Slijivić V. S. Studies on the organ uptake of 51Cr-labeled sheep erythrocytes in the evaluation of stimulation of RES phagocytic function in the mouse. J Reticuloendothel Soc. 1974 Oct;16(4):193–203. [PubMed] [Google Scholar]

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