Skip to main content
NCBI home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1975 Oct;56(5):396–401.

Starch dermatitis: evidence of immunogenicity of surgical glove powder in the guinea-pig.

J B Grant, J D Davies, J Verrier Jones
PMCID: PMC2072775  PMID: 1212422

Abstract

Guinea-pigs immunized by nuchal inoculation of starch glove powder emulsified with Freund's complete adjuvant showed increased thickening of the ear erythema and monoculear inflammation after local injection of 0.1 mg starch compared with similarly treated control animals inoculated with saline and Freund's complete adjuvant. The responses in the ear of the immunized animals were most pronounceed 3-4 weeks after immunization and 24-72 h after local challenge. It is suggested that the inflammatory response in the immunized guinea-pig has 2 components: reaction to a primary irritant in the glove powder and delayed hypersensitivity to an unidentified component of the glove powder.

Full text

PDF
396

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BATES B. GRANULOMATOUS PERITONITIS SECONDARY TO CORN STARCH. Ann Intern Med. 1965 Feb;62:335–347. doi: 10.7326/0003-4819-62-2-335. [DOI] [PubMed] [Google Scholar]
  2. Davies J. D., Neely J. The histopathology of peritoneal starch granulomas. J Pathol. 1972 Aug;107(4):265–278. doi: 10.1002/path.1711070406. [DOI] [PubMed] [Google Scholar]
  3. Holborow E. J., Lowei G. Delayed hypersensitivity and polysaccharide-containing antigens. Br Med Bull. 1967 Jan;23(1):72–75. doi: 10.1093/oxfordjournals.bmb.a070520. [DOI] [PubMed] [Google Scholar]
  4. Lüchtrath H., Dietrich B. Granulome durch moderne Stärkepuder für Operationshandschuhe. Chirurg. 1967 Aug;38(8):360–363. [PubMed] [Google Scholar]
  5. NELSON D. S., BOYDEN S. V. THE CUTANEOUS REACTIVITY OF GUINEA PIGS TO PURE PROTEIN ANTIGENS. I. A CRITICAL EVALUATION OF METHODS FOR THE INDUCTION OF DELAYED-TYPE HYPERSENSITIVITY TO PURE PROTEINS. Int Arch Allergy Appl Immunol. 1964;25:279–303. doi: 10.1159/000229529. [DOI] [PubMed] [Google Scholar]
  6. Neely J., Davies J. D. Starch granulomatosis of the peritoneum. Br Med J. 1971 Sep 11;3(5775):625–629. doi: 10.1136/bmj.3.5775.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. PAPPENHEIMER A. M., SALVIN S. B., UHR J. W. Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes. J Exp Med. 1957 Jan 1;105(1):11–24. doi: 10.1084/jem.105.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Perper J. A., Pidlaon A., Fisher R. S. Granulomatous peritonitis induced by rice-starch glove powder. A clinical and experimental study. Am J Surg. 1971 Dec;122(6):812–817. doi: 10.1016/0002-9610(71)90452-1. [DOI] [PubMed] [Google Scholar]
  9. SALVIN S. B. Occurrence of delayed hypersensitivity during the development of Arthus type hypersensitivity. J Exp Med. 1958 Jan 1;107(1):109–124. doi: 10.1084/jem.107.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Spector W. G. Histology of allergic inflammation. Br Med Bull. 1967 Jan;23(1):35–38. doi: 10.1093/oxfordjournals.bmb.a070513. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES