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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1975 Oct;56(5):444–453.

The surface properties of the lung in rats with alveolar lipo-proteinosis.

A G Heppleston, M McDermott, M M Collins
PMCID: PMC2072780  PMID: 174710

Abstract

The physical behaviour of the intact lungs and of lung extracts from rats affected by alveolar lipo-proteinsosis as a consequence of silica inhalation, was studied by means of pressure volume relations and surface tension area loops. Air inflation of diseased lungs occurred at a lower pressure and collapse was less on deflation than in control specimens, although there appeared to be little change in elastic forces. When saline was used dusted rat lungs showed at higher lung volumes a peculiar hysteresis effect which is attributable to consolidation of alveoli by the lipid material. Extracts from affected lungs showed differences from controls in respect of maximum and minimum surface tensions and stability index but all the values fell within the accepted limits of normal. However, with extracts from pathological lungs the area of the hysteresis loop increased, the shape of the surface tension area curve was abnormal and the percentage compression required to reduce the surface tension to 120 muN/cm fell. Extracts from diseased lungs depressed the maximum surface tension of normal lung extracts and increased the hysteresis area but had little effect on the minimum tension, the stability index or the % compression to achieve 120 muN/cm. The response was thus mainly that of an extract from a dusted rat. The surface activity of phospholipids may be affected by neutral lipid, cholesterol and the products of cell breakdown, all of which occur in the alveolar material. The occurrence within the same lung of compunds which reduce surface tension and others which modify the same lung of compounds which reduce surface tension and others which modify this property suggests that their relative concentrations may determine the overall effectiveness of the lung lining.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS F. H., FUJIWARA T., EMMANOUILIDES G., SCUDDER A. SURFACE PROPERTIES AND LIPIDS FROM LUNGS OF INFANTS WITH HYALINE MEMBRANE DISEASE. J Pediatr. 1965 Feb;66:357–364. doi: 10.1016/s0022-3476(65)80193-7. [DOI] [PubMed] [Google Scholar]
  2. Brumley G. W., Hodson W. A., Avery M. E. Lung phospholipids and surface tension correlations in infants with and without hyaline membrane disease and in adults. Pediatrics. 1967 Jul;40(1):13–19. [PubMed] [Google Scholar]
  3. CLEMENTS J. A., HUSTEAD R. F., JOHNSON R. P., GRIBETZ I. Pulmonary surface tension and alveolar stability. J Appl Physiol. 1961 May;16:444–450. doi: 10.1152/jappl.1961.16.3.444. [DOI] [PubMed] [Google Scholar]
  4. Fisher H. K., Clements J. A., Wright R. R. Pulmonary effects of the herbicide paraquat studied 3 days after injection in rats. J Appl Physiol. 1973 Aug;35(2):268–273. doi: 10.1152/jappl.1973.35.2.268. [DOI] [PubMed] [Google Scholar]
  5. Heppleston A. G. Animal model of human disease. Pulmonary alveolar lipo-proteinosis. Animal model: Silica-induced pulmonary alveolar lipo-proteinosis. Am J Pathol. 1975 Jan;78(1):171–174. [PMC free article] [PubMed] [Google Scholar]
  6. Heppleston A. G., Fletcher K., Wyatt I. Abnormalities of lung lipids following inhalation of quartz. Experientia. 1972 Aug 15;28(8):938–939. doi: 10.1007/BF01924959. [DOI] [PubMed] [Google Scholar]
  7. Heppleston A. G., Fletcher K., Wyatt I. Changes in the composition of lung lipids and the "turnover" of dipalmitoyl lecithin in experimental alveolar lipo-proteinosis induced by inhaled quartz. Br J Exp Pathol. 1974 Aug;55(4):384–395. [PMC free article] [PubMed] [Google Scholar]
  8. Heppleston A. G. The pathological recognition and pathogenesis of emphysema and fibrocystic disease of the lung with special reference to coal workers. Ann N Y Acad Sci. 1972 Dec 29;200:347–369. doi: 10.1111/j.1749-6632.1972.tb40201.x. [DOI] [PubMed] [Google Scholar]
  9. Heppleston A. G., Wright N. A., Stewart J. A. Experimental alveolar lipo-proteinosis following the inhalation of silica. J Pathol. 1970 Aug;101(4):293–307. doi: 10.1002/path.1711010402. [DOI] [PubMed] [Google Scholar]
  10. Heppleston A. G., Young A. E. Alveolar lipo-proteinosis: an ultrastructural comparison of the experimental and human forms. J Pathol. 1972 Jun;107(2):107–117. doi: 10.1002/path.1711070205. [DOI] [PubMed] [Google Scholar]
  11. JOHNSON J. W., PERMUTT S., SIPPLE J. H., SALEM E. S. EFFECT OF INTRA-ALVEOLAR FLUID ON PULMONARY SURFACE TENSION PROPERTIES. J Appl Physiol. 1964 Jul;19:769–777. doi: 10.1152/jappl.1964.19.4.769. [DOI] [PubMed] [Google Scholar]
  12. KLAUS M. H., CLEMENTS J. A., HAVEL R. J. Composition of surface-active material isolated from beef lung. Proc Natl Acad Sci U S A. 1961 Nov 15;47:1858–1859. doi: 10.1073/pnas.47.11.1858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kahana L. M., Aronovitch M. Effects of sulfur dioxide on surface properties of the lung. Am Rev Respir Dis. 1966 Aug;94(2):201–207. doi: 10.1164/arrd.1966.94.2.201. [DOI] [PubMed] [Google Scholar]
  14. Kahana L. M., Aronovitch M. Pulmonary surface tension after sulfur dioxide exposure. Am Rev Respir Dis. 1968 Aug;98(2):311–314. doi: 10.1164/arrd.1968.98.2.311. [DOI] [PubMed] [Google Scholar]
  15. Kuenzig M. C., Hamilton R. W., Jr, Peltier L. F. Dipalmitoyl lecithin: studies on surface properties. J Appl Physiol. 1965 Jul;20(4):779–782. doi: 10.1152/jappl.1965.20.4.779. [DOI] [PubMed] [Google Scholar]
  16. Kuhn C., Györkey F., Levine B. E., Ramirez-Rivera J. Pulmonary alveolar proteinosis. A study using enzyme histochemistry, electron microscopy, and surface tension measurement. Lab Invest. 1966 Feb;15(2):492–509. [PubMed] [Google Scholar]
  17. MILLER D., BONDURANT S. Effects of cigarette smoke on the surface characteristics of lung extracts. Am Rev Respir Dis. 1962 May;85:692–696. doi: 10.1164/arrd.1962.85.5.692. [DOI] [PubMed] [Google Scholar]
  18. Ramirez J., Harlan W. R., Jr Pulmonary alveolar proteinosis. Nature and origin of alveolar lipid. Am J Med. 1968 Oct;45(4):502–512. doi: 10.1016/0002-9343(68)90166-6. [DOI] [PubMed] [Google Scholar]
  19. Rhoades R. A. Effect of inhaled carbon on surface properties of rat lung. Life Sci I. 1972 Jan 1;11(1):33–42. doi: 10.1016/0024-3205(72)90239-1. [DOI] [PubMed] [Google Scholar]
  20. TIERNEY D. F. PULMONARY SURFACTANT IN HEALTH AND DISEASE. Dis Chest. 1965 Mar;47:247–253. doi: 10.1378/chest.47.3.247. [DOI] [PubMed] [Google Scholar]

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