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. 1996 Apr;73(7):887–892. doi: 10.1038/bjc.1996.158

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.

M V Agrez 1, R C Bates 1, D Mitchell 1, N Wilson 1, N Ferguson 1, P Anseline 1, D Sheppard 1
PMCID: PMC2074269  PMID: 8611401

Abstract

Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer.

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Selected References

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