Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1996 Mar;73(5):667–671. doi: 10.1038/bjc.1996.116

Genetic determinants of cutaneous malignant melanoma in Sinclair swine.

J Blangero 1, R G Tissot 1, C W Beattie 1, M S Amoss Jr 1
PMCID: PMC2074359  PMID: 8605105

Abstract

The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leukocyte antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.

Full text

PDF
667

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bale S. J., Chakravarti A., Greene M. H. Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy. Am J Hum Genet. 1986 Feb;38(2):188–196. [PMC free article] [PubMed] [Google Scholar]
  2. Bale S. J., Dracopoli N. C., Tucker M. A., Clark W. H., Jr, Fraser M. C., Stanger B. Z., Green P., Donis-Keller H., Housman D. E., Greene M. H. Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med. 1989 May 25;320(21):1367–1372. doi: 10.1056/NEJM198905253202102. [DOI] [PubMed] [Google Scholar]
  3. Blangero J., MacCluer J. W., Kammerer C. M., Mott G. E., Dyer T. D., McGill H. C., Jr Genetic analysis of apolipoprotein A-I in two dietary environments. Am J Hum Genet. 1990 Sep;47(3):414–428. [PMC free article] [PubMed] [Google Scholar]
  4. Blangero J., Williams-Blangero S., Kammerer C. M., Towne B., Konigsberg L. W. Multivariate genetic analysis of nevus measurements and melanoma. Cytogenet Cell Genet. 1992;59(2-3):179–181. doi: 10.1159/000133238. [DOI] [PubMed] [Google Scholar]
  5. Bonney G. E. Regressive logistic models for familial disease and other binary traits. Biometrics. 1986 Sep;42(3):611–625. [PubMed] [Google Scholar]
  6. Cannon-Albright L. A., Goldgar D. E., Meyer L. J., Lewis C. M., Anderson D. E., Fountain J. W., Hegi M. E., Wiseman R. W., Petty E. M., Bale A. E. Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science. 1992 Nov 13;258(5085):1148–1152. doi: 10.1126/science.1439824. [DOI] [PubMed] [Google Scholar]
  7. Cannon-Albright L. A., Goldgar D. E., Wright E. C., Turco A., Jost M., Meyer L. J., Piepkorn M., Zone J. J., Skolnick M. H. Evidence against the reported linkage of the cutaneous melanoma-dysplastic nevus syndrome locus to chromosome Ip36. Am J Hum Genet. 1990 May;46(5):912–918. [PMC free article] [PubMed] [Google Scholar]
  8. Elston R. C., Stewart J. A general model for the genetic analysis of pedigree data. Hum Hered. 1971;21(6):523–542. doi: 10.1159/000152448. [DOI] [PubMed] [Google Scholar]
  9. Green A., Shilkaitis A., Bratescu L., Amoss M. S., Jr, Beattie C. W. Establishment and characterization of four Sinclair swine cutaneous malignant melanoma cell lines. Cancer Genet Cytogenet. 1992 Jul 1;61(1):77–92. doi: 10.1016/0165-4608(92)90375-i. [DOI] [PubMed] [Google Scholar]
  10. Green A., Swerdlow A. J. Epidemiology of melanocytic nevi. Epidemiol Rev. 1989;11:204–221. doi: 10.1093/oxfordjournals.epirev.a036037. [DOI] [PubMed] [Google Scholar]
  11. Greene M. H., Goldin L. R., Clark W. H., Jr, Lovrien E., Kraemer K. H., Tucker M. A., Elder D. E., Fraser M. C., Rowe S. Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus. Proc Natl Acad Sci U S A. 1983 Oct;80(19):6071–6075. doi: 10.1073/pnas.80.19.6071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gruis N. A., Bergman W., Frants R. R. Locus for susceptibility to melanoma on chromosome lp. N Engl J Med. 1990 Mar 22;322(12):853–854. doi: 10.1056/nejm199003223221217. [DOI] [PubMed] [Google Scholar]
  13. Hasstedt S. J., Moll P. P. Estimation of genetic model parameters: variables correlated with a quantitative phenotype exhibiting major locus inheritance. Genet Epidemiol. 1989;6(2):319–332. doi: 10.1002/gepi.1370060203. [DOI] [PubMed] [Google Scholar]
  14. Hook R. R., Jr, Aultman M. D., Adelstein E. H., Oxenhandler R. W., Millikan L. E., Middleton C. C. Influence of selective breeding on the incidence of melanomas in Sinclair miniature swine. Int J Cancer. 1979 Nov 15;24(5):668–672. doi: 10.1002/ijc.2910240522. [DOI] [PubMed] [Google Scholar]
  15. Hook R. R., Jr, Hamby C. V., Millikan L. E., Berkelhammer J., Stills H. F., Jr, Oxenhandler R. W. Cell-mediated immune reactivity of Sinclair melanoma-bearing swine to 3 M KCl extracts of swine and human melanoma. Int J Cancer. 1983 May 15;31(5):633–637. doi: 10.1002/ijc.2910310516. [DOI] [PubMed] [Google Scholar]
  16. Jones D. H., Amoss M. S., Jr Cell mediated immune response in miniature Sinclair swine bearing cutaneous melanomas. Can J Comp Med. 1982 Apr;46(2):209–211. [PMC free article] [PubMed] [Google Scholar]
  17. Lalouel J. M., Rao D. C., Morton N. E., Elston R. C. A unified model for complex segregation analysis. Am J Hum Genet. 1983 Sep;35(5):816–826. [PMC free article] [PubMed] [Google Scholar]
  18. Millikan L. E., Hook R. R., Manning P. J. Immunobiology of melanoma. Gross and ultrastructural studies in a new melanoma model: the Sinclair swine. Yale J Biol Med. 1973 Dec;46(5):631–645. [PMC free article] [PubMed] [Google Scholar]
  19. Neuman R., Van Eerdewegh P., Moldin S., Rochberg N. Genetic analysis of cutaneous melanoma and dysplastic nevi under varying phenotypic definitions. Cytogenet Cell Genet. 1992;59(2-3):214–216. doi: 10.1159/000133250. [DOI] [PubMed] [Google Scholar]
  20. Rohrer G. A., Alexander L. J., Keele J. W., Smith T. P., Beattie C. W. A microsatellite linkage map of the porcine genome. Genetics. 1994 Jan;136(1):231–245. doi: 10.1093/genetics/136.1.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Speer M. C., Haynes C. S., Pericak-Vance M. A. Segregation analysis in cutaneous malignant melanoma/dysplastic nevus syndrome families. Cytogenet Cell Genet. 1992;59(2-3):225–227. doi: 10.1159/000133254. [DOI] [PubMed] [Google Scholar]
  22. Tissot R. G., Beattie C. W., Amoss M. S., Jr Inheritance of Sinclair swine cutaneous malignant melanoma. Cancer Res. 1987 Nov 1;47(21):5542–5545. [PubMed] [Google Scholar]
  23. Tissot R. G., Beattie C. W., Amoss M. S., Jr The swine leucocyte antigen (SLA) complex and Sinclair swine cutaneous malignant melanoma. Anim Genet. 1989;20(1):51–57. doi: 10.1111/j.1365-2052.1989.tb00841.x. [DOI] [PubMed] [Google Scholar]
  24. Tissot R. G., Beattie C. W., Amoss M. S., Jr, Williams J. D., Schumacher J. Common swine leucocyte antigen (SLA) haplotypes in NIH and Sinclair miniature swine have similar effects on the expression of an inherited melanoma. Anim Genet. 1993 Jun;24(3):191–193. doi: 10.1111/j.1365-2052.1993.tb00286.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES