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. 1996 Feb;73(3):377–381. doi: 10.1038/bjc.1996.64

Hepatocyte growth factor/scatter factor is present in most pleural effusion fluids from cancer patients.

G Eagles 1, A Warn 1, R Y Ball 1, H Baillie-Johnson 1, N Arakaki 1, Y Daikuhara 1, R M Warn 1
PMCID: PMC2074438  PMID: 8562345

Abstract

Pleural effusion samples were obtained from 55 patients with malignant disease, including patients with primary lung cancers and those with a variety of other tumours metastatic to the pleura. The effusions were assayed for the presence of hepatocyte growth factor/scatter factor (HGF/SF), by both ELISA and bioassay. The presence of malignant cells in the effusions was also assessed. Detectable amounts of the factor, as judged by both criteria, were found in over 90% of all the effusions, including those from patients with a wide variety of carcinomas and also lymphomas. A wide range of HGF/SF levels were found for all tumour classes, some effusions containing high levels above 4 ng ml-1. It is concluded that tumours within the pleura and adjacent lung tissue are usually exposed to biologically significant levels of HGF/SF.

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Selected References

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