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. 1996 Feb;73(4):531–538. doi: 10.1038/bjc.1996.92

Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis.

F Janot 1, J Klijanienko 1, A Russo 1, J P Mamet 1, F de Braud 1, A K El-Naggar 1, J P Pignon 1, B Luboinski 1, E Cvitkovic 1
PMCID: PMC2074448  PMID: 8595170

Abstract

The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.

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Selected References

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