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. 1996 Jun;73(11):1381–1386. doi: 10.1038/bjc.1996.262

A non-random deletion in the p53 gene in oral squamous cell carcinoma.

K Nylander 1, E B Schildt 1, M Eriksson 1, A Magnusson 1, C Mehle 1, G Roos 1
PMCID: PMC2074479  PMID: 8645583

Abstract

In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.

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Selected References

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