Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1996 Jun;73(12):1560–1562. doi: 10.1038/bjc.1996.294

The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.

H R Scott 1, D C McMillan 1, A Crilly 1, C S McArdle 1, R Milroy 1
PMCID: PMC2074552  PMID: 8664130

Abstract

Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.

Full text

PDF
1560

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarden L. A., De Groot E. R., Schaap O. L., Lansdorp P. M. Production of hybridoma growth factor by human monocytes. Eur J Immunol. 1987 Oct;17(10):1411–1416. doi: 10.1002/eji.1830171004. [DOI] [PubMed] [Google Scholar]
  2. Espinosa E., Feliu J., Zamora P., González Barón M., Sánchez J. J., Ordón ez A., Espinosa J. Serum albumin and other prognostic factors related to response and survival in patients with advanced non-small cell lung cancer. Lung Cancer. 1995 Mar;12(1-2):67–76. doi: 10.1016/0169-5002(95)00407-r. [DOI] [PubMed] [Google Scholar]
  3. Falconer J. S., Fearon K. C., Plester C. E., Ross J. A., Carter D. C. Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg. 1994 Apr;219(4):325–331. doi: 10.1097/00000658-199404000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Falconer J. S., Fearon K. C., Ross J. A., Elton R., Wigmore S. J., Garden O. J., Carter D. C. Acute-phase protein response and survival duration of patients with pancreatic cancer. Cancer. 1995 Apr 15;75(8):2077–2082. doi: 10.1002/1097-0142(19950415)75:8<2077::aid-cncr2820750808>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  5. Fearon K. C. The Sir David Cuthbertson Medal Lecture 1991. The mechanisms and treatment of weight loss in cancer. Proc Nutr Soc. 1992 Aug;51(2):251–265. doi: 10.1079/pns19920036. [DOI] [PubMed] [Google Scholar]
  6. Heinrich P. C., Castell J. V., Andus T. Interleukin-6 and the acute phase response. Biochem J. 1990 Feb 1;265(3):621–636. doi: 10.1042/bj2650621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ihde D. C., Minna J. D. Non-small cell lung cancer. Part II: Treatment. Curr Probl Cancer. 1991 May-Jun;15(3):105–154. doi: 10.1016/0147-0272(91)90012-y. [DOI] [PubMed] [Google Scholar]
  8. Mayer P., Geissler K., Valent P., Ceska M., Bettelheim P., Liehl E. Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates. Exp Hematol. 1991 Aug;19(7):688–696. [PubMed] [Google Scholar]
  9. McMillan D. C., Leen E., Smith J., Sturgeon C., Preston T., Cooke T. G., McArdle C. S. Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients. Eur J Surg Oncol. 1995 Oct;21(5):531–534. doi: 10.1016/s0748-7983(95)97157-2. [DOI] [PubMed] [Google Scholar]
  10. McMillan D. C., Preston T., Fearon K. C., Burns H. J., Slater C., Shenkin A. Protein synthesis in cancer patients with inflammatory response: investigations with [15N]glycine. Nutrition. 1994 May-Jun;10(3):232–240. [PubMed] [Google Scholar]
  11. Mountain C. F. A new international staging system for lung cancer. Chest. 1986 Apr;89(4 Suppl):225S–233S. doi: 10.1378/chest.89.4_supplement.225s. [DOI] [PubMed] [Google Scholar]
  12. Ohe Y., Podack E. R., Olsen K. J., Miyahara Y., Miura K., Saito H., Koishihara Y., Ohsugi Y., Ohira T., Nishio K. Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice. Br J Cancer. 1993 May;67(5):939–944. doi: 10.1038/bjc.1993.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Preston T., Fearon K. C., McMillan D. C., Winstanley F. P., Slater C., Shenkin A., Carter D. C. Effect of ibuprofen on the acute-phase response and protein metabolism in patients with cancer and weight loss. Br J Surg. 1995 Feb;82(2):229–234. doi: 10.1002/bjs.1800820233. [DOI] [PubMed] [Google Scholar]
  14. Selberg O., McMillan D. C., Preston T., Carse H., Shenkin A., Burns H. J. Palmitate turnover and its response to glucose infusion in weight-losing cancer patients. Clin Nutr. 1990 Jun;9(3):150–156. doi: 10.1016/0261-5614(90)90047-v. [DOI] [PubMed] [Google Scholar]
  15. Splinter T. A. Management of non-small cell and small cell lung cancer. Curr Opin Oncol. 1991 Apr;3(2):312–319. doi: 10.1097/00001622-199104000-00012. [DOI] [PubMed] [Google Scholar]
  16. Sridhar K. S., Bounassi M. J., Raub W., Jr, Richman S. P. Clinical features of adenosquamous lung carcinoma in 127 patients. Am Rev Respir Dis. 1990 Jul;142(1):19–23. doi: 10.1164/ajrccm/142.1.19. [DOI] [PubMed] [Google Scholar]
  17. Strassmann G., Fong M., Kenney J. S., Jacob C. O. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest. 1992 May;89(5):1681–1684. doi: 10.1172/JCI115767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Thorogood J., Bulman A. S., Collins T., Ash D. The use of discriminant analysis to guide palliative treatment for lung cancer patients. Clin Oncol (R Coll Radiol) 1992 Jan;4(1):22–26. doi: 10.1016/s0936-6555(05)80767-8. [DOI] [PubMed] [Google Scholar]
  19. Wigmore S. J., Falconer J. S., Plester C. E., Ross J. A., Maingay J. P., Carter D. C., Fearon K. C. Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients. Br J Cancer. 1995 Jul;72(1):185–188. doi: 10.1038/bjc.1995.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Yanagawa H., Sone S., Takahashi Y., Haku T., Yano S., Shinohara T., Ogura T. Serum levels of interleukin 6 in patients with lung cancer. Br J Cancer. 1995 May;71(5):1095–1098. doi: 10.1038/bjc.1995.212. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES