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. 1996 Jul;74(2):251–254. doi: 10.1038/bjc.1996.346

Chromosome rearrangements in synovial chondromatous lesions.

F Mertens 1, K Jonsson 1, H Willén 1, A Rydholm 1, A Kreicbergs 1, L Eriksson 1, G Olsson-Sandin 1, F Mitelman 1, N Mandahl 1
PMCID: PMC2074582  PMID: 8688330

Abstract

Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were found in the three cases of chondromatosis: case 1, 47,XY,der(1)inv(1)(p13q25)del (1)(q25q32), t(1;12)(q25;q13), + 5,der(12)add(12)(p11)t(1;12)(p22;q13); case 2, 47,XY,add(10)(q26), + 20/46 idem,-6/46,XY,t(2;4)(q33;q21), add(21)(p11); and case 3, 44,XY,add(1)(p36), del(1)(p13p22),add(6)(p25), del(7) (q22q32),del(10)(q21),add(11)(q13),-17,-18. The cytogenetic findings strongly suggest that synovial chondro-matosis is a clonal proliferation. Apart from a near-diploid chromosome number, the only recurrent cytogenetic features among the four cases were loss of band 10q26 and rearrangements of 1p13 and 12q13, found in two cases each. While chromosome bands 1p13 and 10q26 have not been reported to be involved in other types of benign chondromatous lesions, the 12q13-15 segment is recurrently rearranged in a variety of chondromatous tumours, e.g. pulmonary chondroid hamartomas. The present finding of translocations affecting band 12q13 in two of the cases emphasises that, irrespective of the anatomical localisation of the tumours, rearrangements of genes in 12q13-15 are important in the development of a large subset of benign and malignant cartilage-forming tumours.

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Selected References

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  1. Ashar H. R., Fejzo M. S., Tkachenko A., Zhou X., Fletcher J. A., Weremowicz S., Morton C. C., Chada K. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell. 1995 Jul 14;82(1):57–65. doi: 10.1016/0092-8674(95)90052-7. [DOI] [PubMed] [Google Scholar]
  2. Bertoni F., Unni K. K., Beabout J. W., Sim F. H. Chondrosarcomas of the synovium. Cancer. 1991 Jan 1;67(1):155–162. doi: 10.1002/1097-0142(19910101)67:1<155::aid-cncr2820670127>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  3. Bridge J. A., Bhatia P. S., Anderson J. R., Neff J. R. Biologic and clinical significance of cytogenetic and molecular cytogenetic abnormalities in benign and malignant cartilaginous lesions. Cancer Genet Cytogenet. 1993 Sep;69(2):79–90. doi: 10.1016/0165-4608(93)90080-6. [DOI] [PubMed] [Google Scholar]
  4. Bridge J. A., Persons D. L., Neff J. R., Bhatia P. Clonal karyotypic aberrations in enchondromas. Cancer Detect Prev. 1992;16(4):215–219. [PubMed] [Google Scholar]
  5. Bridge J. A., Sanger W. G., Neff J. R. Translocations involving chromosomes 2 and 13 in benign and malignant cartilaginous neoplasms. Cancer Genet Cytogenet. 1989 Mar;38(1):83–88. doi: 10.1016/0165-4608(89)90168-4. [DOI] [PubMed] [Google Scholar]
  6. Dal Cin P., Kools P., De Jonge I., Moerman P., Van de Ven W., Van den Berghe H. Rearrangement of 12q14-15 in pulmonary chondroid hamartoma. Genes Chromosomes Cancer. 1993 Oct;8(2):131–133. doi: 10.1002/gcc.2870080211. [DOI] [PubMed] [Google Scholar]
  7. Dal Cin P., Sciot R., Samson I., De Smet L., De Wever I., Van Damme B., Van den Berghe H. Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). Cancer Res. 1994 Aug 1;54(15):3986–3987. [PubMed] [Google Scholar]
  8. Edeiken J., Edeiken B. S., Ayala A. G., Raymond A. K., Murray J. A., Guo S. Q. Giant solitary synovial chondromatosis. Skeletal Radiol. 1994 Jan;23(1):23–29. doi: 10.1007/BF00203697. [DOI] [PubMed] [Google Scholar]
  9. Fletcher J. A., Longtine J., Wallace K., Mentzer S. J., Sugarbaker D. J. Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer. 1995 Mar;12(3):220–223. doi: 10.1002/gcc.2870120310. [DOI] [PubMed] [Google Scholar]
  10. Fletcher J. A., Pinkus G. S., Donovan K., Naeem R., Sugarbaker D. J., Mentzer S., Pinkus J. L., Longtine J. Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma. Cancer Res. 1992 Nov 15;52(22):6224–6228. [PubMed] [Google Scholar]
  11. Fletcher J. A., Pinkus G. S., Weidner N., Morton C. C. Lineage-restricted clonality in biphasic solid tumors. Am J Pathol. 1991 May;138(5):1199–1207. [PMC free article] [PubMed] [Google Scholar]
  12. Johansson M., Dietrich C., Mandahl N., Hambraeus G., Johansson L., Clausen P. P., Mitelman F., Heim S. Recombinations of chromosomal bands 6p21 and 14q24 characterise pulmonary hamartomas. Br J Cancer. 1993 Jun;67(6):1236–1241. doi: 10.1038/bjc.1993.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johansson M., Heim S., Mandahl N., Johansson L., Hambraeus G., Mitelman F. t(3;6;14)(p21;p21;q24) as the sole clonal chromosome abnormality in a hamartoma of the lung. Cancer Genet Cytogenet. 1992 Jun;60(2):219–220. doi: 10.1016/0165-4608(92)90026-5. [DOI] [PubMed] [Google Scholar]
  14. Mandahl N., Heim S., Arheden K., Rydholm A., Willén H., Mitelman F. Chromosomal rearrangements in chondromatous tumors. Cancer. 1990 Jan 15;65(2):242–248. doi: 10.1002/1097-0142(19900115)65:2<242::aid-cncr2820650211>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  15. Mandahl N., Heim S., Arheden K., Rydholm A., Willén H., Mitelman F. Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas. Hum Genet. 1988 Jul;79(3):203–208. doi: 10.1007/BF00366238. [DOI] [PubMed] [Google Scholar]
  16. Mandahl N., Willén H., Rydholm A., Heim S., Mitelman F. Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma. Genes Chromosomes Cancer. 1993 Feb;6(2):121–123. doi: 10.1002/gcc.2870060210. [DOI] [PubMed] [Google Scholar]
  17. Mark J., Wedell B., Dahlenfors R., Grepp C., Burian P. Human benign chondroblastoma with a pseudodiploid stemline characterized by a complex and balanced translocation. Cancer Genet Cytogenet. 1992 Jan;58(1):14–17. doi: 10.1016/0165-4608(92)90126-s. [DOI] [PubMed] [Google Scholar]
  18. Mertens F., Rydholm A., Kreicbergs A., Willén H., Jonsson K., Heim S., Mitelman F., Mandahl N. Loss of chromosome band 8q24 in sporadic osteocartilaginous exostoses. Genes Chromosomes Cancer. 1994 Jan;9(1):8–12. doi: 10.1002/gcc.2870090103. [DOI] [PubMed] [Google Scholar]
  19. Schoenmakers E. F., Wanschura S., Mols R., Bullerdiek J., Van den Berghe H., Van de Ven W. J. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet. 1995 Aug;10(4):436–444. doi: 10.1038/ng0895-436. [DOI] [PubMed] [Google Scholar]
  20. Tarkkanen M., Kaipainen A., Karaharju E., Böhling T., Szymanska J., Heliö H., Kivioja A., Elomaa I., Knuutila S. Cytogenetic study of 249 consecutive patients examined for a bone tumor. Cancer Genet Cytogenet. 1993 Jul 1;68(1):1–21. doi: 10.1016/0165-4608(93)90068-w. [DOI] [PubMed] [Google Scholar]
  21. Teyssier J. R., Ferre D. Frequent clonal chromosomal changes in human non-malignant tumors. Int J Cancer. 1989 Nov 15;44(5):828–832. doi: 10.1002/ijc.2910440514. [DOI] [PubMed] [Google Scholar]
  22. Teyssier J. R. Nonrandom chromosomal changes in human solid tumors: application of an improved culture method. J Natl Cancer Inst. 1987 Dec;79(6):1189–1198. [PubMed] [Google Scholar]

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