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British Journal of Cancer logoLink to British Journal of Cancer
. 1996 Sep;74(5):836–838. doi: 10.1038/bjc.1996.445

Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt.

A Lafuente 1, M M Zakahary 1, M A el-Aziz 1, C Ascaso 1, M J Lafuente 1, M Trias 1, P Carretero 1
PMCID: PMC2074697  PMID: 8795591

Abstract

In this study we show an effect of the glutathione-S-transferase M1 (GSTM1) null phenotype on the risk for squamous cell carcinoma (SCC) of the bladder among male smokers in Egypt, with an adjusted odds ratio of 4.8 (95% confidence interval: 1.06-21.77). However, no overall effect of the GSTM1 null phenotype on the risk for bladder SCC was observed.

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Selected References

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  1. Anttila S., Luostarinen L., Hirvonen A., Elovaara E., Karjalainen A., Nurminen T., Hayes J. D., Vainio H., Ketterer B. Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure. Cancer Res. 1995 Aug 1;55(15):3305–3309. [PubMed] [Google Scholar]
  2. Badawi A. F., Mostafa M. H., O'Connor P. J. Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. Cancer Lett. 1992 Apr 30;63(3):171–188. doi: 10.1016/0304-3835(92)90259-x. [DOI] [PubMed] [Google Scholar]
  3. Bell D. A., Taylor J. A., Paulson D. F., Robertson C. N., Mohler J. L., Lucier G. W. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst. 1993 Jul 21;85(14):1159–1164. doi: 10.1093/jnci/85.14.1159. [DOI] [PubMed] [Google Scholar]
  4. Brockmöller J., Kerb R., Drakoulis N., Nitz M., Roots I. Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controls. Cancer Res. 1993 Mar 1;53(5):1004–1011. [PubMed] [Google Scholar]
  5. Brockmöller J., Kerb R., Drakoulis N., Staffeldt B., Roots I. Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. Cancer Res. 1994 Aug 1;54(15):4103–4111. [PubMed] [Google Scholar]
  6. Cole P., Monson R. R., Haning H., Friedell G. H. Smoking and cancer f the lower urinary tract. N Engl J Med. 1971 Jan 21;284(3):129–134. doi: 10.1056/NEJM197101212840304. [DOI] [PubMed] [Google Scholar]
  7. Daly A. K., Thomas D. J., Cooper J., Pearson W. R., Neal D. E., Idle J. R. Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. BMJ. 1993 Aug 21;307(6902):481–482. doi: 10.1136/bmj.307.6902.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Habuchi T., Takahashi R., Yamada H., Ogawa O., Kakehi Y., Ogura K., Hamazaki S., Toguchida J., Ishizaki K., Fujita J. Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer. Cancer Res. 1993 Aug 15;53(16):3795–3799. [PubMed] [Google Scholar]
  9. Hayashi S., Watanabe J., Kawajiri K. High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes. Jpn J Cancer Res. 1992 Aug;83(8):866–870. doi: 10.1111/j.1349-7006.1992.tb01992.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hussey A. J., Stockman P. K., Beckett G. J., Hayes J. D. Variations in the glutathione S-transferase subunits expressed in human livers. Biochim Biophys Acta. 1986 Nov 7;874(1):1–12. doi: 10.1016/0167-4838(86)90094-4. [DOI] [PubMed] [Google Scholar]
  11. Kensler T., Styczynski P., Groopman J., Helzlsouer K., Curphey T., Maxuitenko Y., Roebuck B. D. Mechanisms of chemoprotection by oltipraz. J Cell Biochem Suppl. 1992;16I:167–172. doi: 10.1002/jcb.240501331. [DOI] [PubMed] [Google Scholar]
  12. Ketterer B., Meyer D. J. Glutathione transferases: a possible role in the detoxication and repair of DNA and lipid hydroperoxides. Mutat Res. 1989 Sep;214(1):33–40. doi: 10.1016/0027-5107(89)90195-4. [DOI] [PubMed] [Google Scholar]
  13. Lafuente A., Molina R., Palou J., Castel T., Moral A., Trias M. Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group. Br J Cancer. 1995 Aug;72(2):324–326. doi: 10.1038/bjc.1995.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lafuente A., Pujol F., Carretero P., Villa J. P., Cuchi A. Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers. Cancer Lett. 1993 Jan 15;68(1):49–54. doi: 10.1016/0304-3835(93)90218-x. [DOI] [PubMed] [Google Scholar]
  15. Lin H. J., Han C. Y., Bernstein D. A., Hsiao W., Lin B. K., Hardy S. Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis. 1994 May;15(5):1077–1081. doi: 10.1093/carcin/15.5.1077. [DOI] [PubMed] [Google Scholar]
  16. Mahgoub A., Idle J. R., Smith R. L. A population and familial study of the defective alicyclic hydroxylation of debrisoquine among Egyptians. Xenobiotica. 1979 Jan;9(1):51–56. doi: 10.3109/00498257909034703. [DOI] [PubMed] [Google Scholar]
  17. Ryberg D., Kure E., Lystad S., Skaug V., Stangeland L., Mercy I., Børresen A. L., Haugen A. p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer. Cancer Res. 1994 Mar 15;54(6):1551–1555. [PubMed] [Google Scholar]
  18. Seidegård J., Pero R. W., Markowitz M. M., Roush G., Miller D. G., Beattie E. J. Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis. 1990 Jan;11(1):33–36. doi: 10.1093/carcin/11.1.33. [DOI] [PubMed] [Google Scholar]
  19. Singh S. V., Xu B. H., Tkalcevic G. T., Gupta V., Roberts B., Ruiz P. Glutathione-linked detoxification pathway in normal and malignant human bladder tissue. Cancer Lett. 1994 Feb 28;77(1):15–24. doi: 10.1016/0304-3835(94)90342-5. [DOI] [PubMed] [Google Scholar]
  20. Wynder E. L., Goldsmith R. The epidemiology of bladder cancer: a second look. Cancer. 1977 Sep;40(3):1246–1268. doi: 10.1002/1097-0142(197709)40:3<1246::aid-cncr2820400340>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  21. Zhong S., Wyllie A. H., Barnes D., Wolf C. R., Spurr N. K. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993 Sep;14(9):1821–1824. doi: 10.1093/carcin/14.9.1821. [DOI] [PubMed] [Google Scholar]

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