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British Journal of Cancer logoLink to British Journal of Cancer
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. 1996 Sep;74(6):995–996. doi: 10.1038/bjc.1996.477

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity.

D Ross, R D Traver, D Siegel, B L Kuehl, V Misra, A M Rauth
PMCID: PMC2074732  PMID: 8826876

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eickelmann P., Ebert T., Warskulat U., Schulz W. A., Sies H. Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines. Carcinogenesis. 1994 Feb;15(2):219–225. doi: 10.1093/carcin/15.2.219. [DOI] [PubMed] [Google Scholar]
  2. Eickelmann P., Schulz W. A., Rohde D., Schmitz-Dräger B., Sies H. Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line. Biol Chem Hoppe Seyler. 1994 Jul;375(7):439–445. doi: 10.1515/bchm3.1994.375.7.439. [DOI] [PubMed] [Google Scholar]
  3. Gasdaska P. Y., Fisher H., Powis G. An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues. Cancer Res. 1995 Jun 15;55(12):2542–2547. [PubMed] [Google Scholar]
  4. Kolesar J. M., Kuhn J. G., Burris H. A., 3rd Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. J Natl Cancer Inst. 1995 Jul 5;87(13):1022–1024. doi: 10.1093/jnci/87.13.1022-a. [DOI] [PubMed] [Google Scholar]
  5. Kuehl B. L., Paterson J. W., Peacock J. W., Paterson M. C., Rauth A. M. Presence of a heterozygous substitution and its relationship to DT-diaphorase activity. Br J Cancer. 1995 Sep;72(3):555–561. doi: 10.1038/bjc.1995.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ross D., Beall H., Traver R. D., Siegel D., Phillips R. M., Gibson N. W. Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Oncol Res. 1994;6(10-11):493–500. [PubMed] [Google Scholar]
  7. Ross D., Siegel D., Beall H., Prakash A. S., Mulcahy R. T., Gibson N. W. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. Cancer Metastasis Rev. 1993 Jun;12(2):83–101. doi: 10.1007/BF00689803. [DOI] [PubMed] [Google Scholar]
  8. Rosvold E. A., McGlynn K. A., Lustbader E. D., Buetow K. H. Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics. 1995 Aug;5(4):199–206. doi: 10.1097/00008571-199508000-00003. [DOI] [PubMed] [Google Scholar]
  9. Siegel D., Gibson N. W., Preusch P. C., Ross D. Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res. 1990 Nov 15;50(22):7293–7300. [PubMed] [Google Scholar]
  10. Traver R. D., Horikoshi T., Danenberg K. D., Stadlbauer T. H., Danenberg P. V., Ross D., Gibson N. W. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res. 1992 Feb 15;52(4):797–802. [PubMed] [Google Scholar]

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