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. 1996 Sep;74(6):975–979. doi: 10.1038/bjc.1996.468

Recurrences and related characteristics of gastric cancer.

Y Maehara 1, Y Emi 1, H Baba 1, Y Adachi 1, K Akazawa 1, Y Ichiyoshi 1, K Sugimachi 1
PMCID: PMC2074740  PMID: 8826869

Abstract

We analysed data on 1117 patients with gastric cancer who were treated by curative resection. Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour location, tumour tissue differentiation, growth pattern, depth of invasion, lymphatic and vascular invasion and lymph node metastasis. In proportion to the growth potential, determined by the level of proliferating cell nuclear antigen (PCNA) labelling, the death related to a recurrence was increased and the prognosis was poorer. Multivariate analysis showed that the three factors of serosal invasion, PCNA labelling index and lymph node dissection were independent prognostic factors. When sites of recurrence were analysed regarding each depth of invasion, haematogenous recurrence, in particular in the liver, occurred even in cases of an early invasion and many types of recurrences, including peritoneal recurrence, were noted in patients with an advanced state of invasion.

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Selected References

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  1. Adachi Y., Kamakura T., Mori M., Baba H., Maehara Y., Sugimachi K. Prognostic significance of the number of positive lymph nodes in gastric carcinoma. Br J Surg. 1994 Mar;81(3):414–416. doi: 10.1002/bjs.1800810331. [DOI] [PubMed] [Google Scholar]
  2. Baba H., Korenaga D., Okamura T., Saito A., Sugimachi K. Prognostic factors in gastric cancer with serosal invasion. Univariate and multivariate analyses. Arch Surg. 1989 Sep;124(9):1061–1064. doi: 10.1001/archsurg.1989.01410090071015. [DOI] [PubMed] [Google Scholar]
  3. Baba H., Maehara Y., Takeuchi H., Inutsuka S., Okuyama T., Adachi Y., Akazawa K., Sugimachi K. Effect of lymph node dissection on the prognosis in patients with node-negative early gastric cancer. Surgery. 1995 Feb;117(2):165–169. doi: 10.1016/s0039-6060(05)80080-7. [DOI] [PubMed] [Google Scholar]
  4. Bozzetti F., Bonfanti G., Bufalino R., Menotti V., Persano S., Andreola S., Doci R., Gennari L. Adequacy of margins of resection in gastrectomy for cancer. Ann Surg. 1982 Dec;196(6):685–690. doi: 10.1097/00000658-198212001-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hall P. A., Levison D. A., Woods A. L., Yu C. C., Kellock D. B., Watkins J. A., Barnes D. M., Gillett C. E., Camplejohn R., Dover R. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol. 1990 Dec;162(4):285–294. doi: 10.1002/path.1711620403. [DOI] [PubMed] [Google Scholar]
  6. Hirono Y., Tsugawa K., Fushida S., Ninomiya I., Yonemura Y., Miyazaki I., Endou Y., Tanaka M., Sasaki T. Amplification of epidermal growth factor receptor gene and its relationship to survival in human gastric cancer. Oncology. 1995 May-Jun;52(3):182–188. doi: 10.1159/000227455. [DOI] [PubMed] [Google Scholar]
  7. Ichiyoshi Y., Toda T., Minamisono Y., Nagasaki S., Yakeishi Y., Sugimachi K. Recurrence in early gastric cancer. Surgery. 1990 May;107(5):489–495. [PubMed] [Google Scholar]
  8. Joypaul B. V., Hopwood D., Newman E. L., Qureshi S., Grant A., Ogston S. A., Lane D. P., Cuschieri A. The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma. Br J Cancer. 1994 May;69(5):943–946. doi: 10.1038/bjc.1994.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kakeji Y., Maehara Y., Adachi Y., Baba H., Mori M., Furusawa M., Sugimachi K. Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. Br J Cancer. 1994 Apr;69(4):749–753. doi: 10.1038/bjc.1994.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kawasaki S. [A clinicopathological study on upward intramural extension of cancer of the stomach (author's transl)]. Fukuoka Igaku Zasshi. 1975 Jan;66(1):1–23. [PubMed] [Google Scholar]
  11. Korenaga D., Okamura T., Baba H., Saito A., Sugimachi K. Results of resection of gastric cancer extending to adjacent organs. Br J Surg. 1988 Jan;75(1):12–15. doi: 10.1002/bjs.1800750106. [DOI] [PubMed] [Google Scholar]
  12. Korenaga D., Okamura T., Saito A., Baba H., Sugimachi K. DNA ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer. Cancer. 1988 Jul 15;62(2):309–313. doi: 10.1002/1097-0142(19880715)62:2<309::aid-cncr2820620214>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  13. Lee E. Y., Cibull M. L., Strodel W. E., Haley J. V. Expression of HER-2/neu oncoprotein and epidermal growth factor receptor and prognosis in gastric carcinoma. Arch Pathol Lab Med. 1994 Mar;118(3):235–239. [PubMed] [Google Scholar]
  14. Maeda K., Chung Y. S., Onoda N., Kato Y., Nitta A., Arimoto Y., Yamada N., Kondo Y., Sowa M. Proliferating cell nuclear antigen labeling index of preoperative biopsy specimens in gastric carcinoma with special reference to prognosis. Cancer. 1994 Feb 1;73(3):528–533. doi: 10.1002/1097-0142(19940201)73:3<528::aid-cncr2820730306>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  15. Maehara Y., Moriguchi S., Kakeji Y., Kohnoe S., Korenaga D., Haraguchi M., Sugimachi K. Pertinent risk factors and gastric carcinoma with synchronous peritoneal dissemination or liver metastasis. Surgery. 1991 Nov;110(5):820–823. [PubMed] [Google Scholar]
  16. Maehara Y., Moriguchi S., Yoshida M., Takahashi I., Korenaga D., Sugimachi K. Splenectomy does not correlate with length of survival in patients undergoing curative total gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer. 1991 Jun 15;67(12):3006–3009. doi: 10.1002/1097-0142(19910615)67:12<3006::aid-cncr2820671213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  17. Maehara Y., Okuyama T., Kakeji Y., Baba H., Furusawa M., Sugimachi K. Postoperative immunochemotherapy including streptococcal lysate OK-432 is effective for patients with gastric cancer and serosal invasion. Am J Surg. 1994 Jul;168(1):36–40. doi: 10.1016/s0002-9610(05)80068-6. [DOI] [PubMed] [Google Scholar]
  18. Maehara Y., Okuyama T., Moriguchi S., Orita H., Kusumoto H., Korenaga D., Sugimachi K. Prophylactic lymph node dissection in patients with advanced gastric cancer promotes increased survival time. Cancer. 1992 Jul 15;70(2):392–395. doi: 10.1002/1097-0142(19920715)70:2<392::aid-cncr2820700204>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  19. Maehara Y., Okuyama T., Oshiro T., Baba H., Anai H., Akazawa K., Sugimachi K. Early carcinoma of the stomach. Surg Gynecol Obstet. 1993 Dec;177(6):593–597. [PubMed] [Google Scholar]
  20. Maehara Y., Oshiro T., Baba H., Ohno S., Kohnoe S., Sugimachi K. Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. Surgery. 1995 Apr;117(4):380–385. doi: 10.1016/s0039-6060(05)80056-x. [DOI] [PubMed] [Google Scholar]
  21. Maehara Y., Oshiro T., Oiwa H., Oda S., Baba H., Akazawa K., Sugimachi K. Gastric carcinoma in patients over 70 years of age. Br J Surg. 1995 Jan;82(1):102–105. doi: 10.1002/bjs.1800820134. [DOI] [PubMed] [Google Scholar]
  22. Maehara Y., Sugimachi K., Akagi M., Kakegawa T., Shimazu H., Tomita M. Serum carcinoembryonic antigen level increases correlate with tumor progression in patients with differentiated gastric carcinoma following noncurative resection. Cancer Res. 1990 Jul 1;50(13):3952–3955. [PubMed] [Google Scholar]
  23. Moreaux J., Bougaran J. Early gastric cancer. A 25-year surgical experience. Ann Surg. 1993 Apr;217(4):347–355. doi: 10.1097/00000658-199304000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Moriguchi S., Maehara Y., Korenaga D., Sugimachi K., Nose Y. Risk factors which predict pattern of recurrence after curative surgery for patients with advanced gastric cancer. Surg Oncol. 1992 Oct;1(5):341–346. doi: 10.1016/0960-7404(92)90034-i. [DOI] [PubMed] [Google Scholar]
  25. Noguchi Y. Blood vessel invasion in gastric carcinoma. Surgery. 1990 Feb;107(2):140–148. [PubMed] [Google Scholar]
  26. Orita H., Matsusaka T., Wakasugi K., Kume K., Fujinaga Y., Fuchigami T., Iwashita A. Clinicopathologic evaluation of recurrence in early gastric cancer. Surg Today. 1992;22(1):19–23. doi: 10.1007/BF00326120. [DOI] [PubMed] [Google Scholar]
  27. Waseem N. H., Lane D. P. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. J Cell Sci. 1990 May;96(Pt 1):121–129. doi: 10.1242/jcs.96.1.121. [DOI] [PubMed] [Google Scholar]

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