Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1996 Sep;74(6):942–946. doi: 10.1038/bjc.1996.461

Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.

J Randerson 1, L Cawkwell 1, A Jack 1, F Lewis 1, P Johnson 1, P Evans 1, S Barrans 1, G J Morgan 1
PMCID: PMC2074751  PMID: 8826862

Abstract

Twenty-four cases of histologically defined follicle centre cell (FCC) lymphoma have been examined for allele imbalance at 19 microsatellite loci spanning the length of chromosome 6, including six markers within the major histocompatibility complex (MHC), using fluorescent polymerase chain reaction (PCR) to amplify microsatellites. Nineteen cases were observed in which imbalance of one or more markers on chromosome 6 had occurred (79%). The frequency of allele imbalance was significantly higher on 6p than 6q, and two regions of deletions, 6p24-25 and 6p21.3-23, were identified in which the loci showed a significantly high allele imbalance frequency.

Full text

PDF
942

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell S. M., Kelly S. A., Hoyle J. A., Lewis F. A., Taylor G. R., Thompson H., Dixon M. F., Quirke P. c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis. Br J Cancer. 1991 Jul;64(1):174–178. doi: 10.1038/bjc.1991.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carrington M., Dean M. A polymorphic dinucleotide repeat in the third intron of TAP1. Hum Mol Genet. 1994 Jan;3(1):218–218. doi: 10.1093/hmg/3.1.218. [DOI] [PubMed] [Google Scholar]
  3. Cawkwell L., Bell S. M., Lewis F. A., Dixon M. F., Taylor G. R., Quirke P. Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology. Br J Cancer. 1993 Jun;67(6):1262–1267. doi: 10.1038/bjc.1993.236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cawkwell L., Lewis F. A., Quirke P. Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer. 1994 Nov;70(5):813–818. doi: 10.1038/bjc.1994.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Foulkes W. D., Ragoussis J., Stamp G. W., Allan G. J., Trowsdale J. Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma. Br J Cancer. 1993 Mar;67(3):551–559. doi: 10.1038/bjc.1993.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gaidano G., Hauptschein R. S., Parsa N. Z., Offit K., Rao P. H., Lenoir G., Knowles D. M., Chaganti R. S., Dalla-Favera R. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma. Blood. 1992 Oct 1;80(7):1781–1787. [PubMed] [Google Scholar]
  7. Gyapay G., Morissette J., Vignal A., Dib C., Fizames C., Millasseau P., Marc S., Bernardi G., Lathrop M., Weissenbach J. The 1993-94 Généthon human genetic linkage map. Nat Genet. 1994 Jun;7(2 Spec No):246–339. doi: 10.1038/ng0694supp-246. [DOI] [PubMed] [Google Scholar]
  8. Korsmeyer S. J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood. 1992 Aug 15;80(4):879–886. [PubMed] [Google Scholar]
  9. Menasce L. P., Orphanos V., Santibanez-Koref M., Boyle J. M., Harrison C. J. Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia. Genes Chromosomes Cancer. 1994 Aug;10(4):286–288. doi: 10.1002/gcc.2870100411. [DOI] [PubMed] [Google Scholar]
  10. Nedospasov S. A., Udalova I. A., Kuprash D. V., Turetskaya R. L. DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene. J Immunol. 1991 Aug 1;147(3):1053–1059. [PubMed] [Google Scholar]
  11. Offit K., Parsa N. Z., Gaidano G., Filippa D. A., Louie D., Pan D., Jhanwar S. C., Dalla-Favera R., Chaganti R. S. 6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma. Blood. 1993 Oct 1;82(7):2157–2162. [PubMed] [Google Scholar]
  12. Orphanos V., McGown G., Boyle J. M., Santibanez-Koref M. Thirteen dinucleotide repeat polymorphisms on chromosome 6. Hum Mol Genet. 1993 Dec;2(12):2196–2196. doi: 10.1093/hmg/2.12.2196. [DOI] [PubMed] [Google Scholar]
  13. Sander C. A., Yano T., Clark H. M., Harris C., Longo D. L., Jaffe E. S., Raffeld M. p53 mutation is associated with progression in follicular lymphomas. Blood. 1993 Oct 1;82(7):1994–2004. [PubMed] [Google Scholar]
  14. Schouten H. C., Sanger W. G., Weisenburger D. D., Armitage J. O. Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma. Nebraska Lymphoma Study Group. Cancer Genet Cytogenet. 1990 Jul 1;47(1):73–82. doi: 10.1016/0165-4608(90)90265-c. [DOI] [PubMed] [Google Scholar]
  15. Solomon E., Voss R., Hall V., Bodmer W. F., Jass J. R., Jeffreys A. J., Lucibello F. C., Patel I., Rider S. H. Chromosome 5 allele loss in human colorectal carcinomas. Nature. 1987 Aug 13;328(6131):616–619. doi: 10.1038/328616a0. [DOI] [PubMed] [Google Scholar]
  16. Weber J. L., Kwitek A. E., May P. E., Zoghbi H. Y. Dinucleotide repeat polymorphism at the D6S105 locus. Nucleic Acids Res. 1991 Feb 25;19(4):968–968. doi: 10.1093/nar/19.4.968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Weissenbach J., Gyapay G., Dib C., Vignal A., Morissette J., Millasseau P., Vaysseix G., Lathrop M. A second-generation linkage map of the human genome. Nature. 1992 Oct 29;359(6398):794–801. doi: 10.1038/359794a0. [DOI] [PubMed] [Google Scholar]
  18. Yandell D. W., Dryja T. P. Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing. Am J Hum Genet. 1989 Oct;45(4):547–555. [PMC free article] [PubMed] [Google Scholar]
  19. Yunis J. J., Oken M. M., Theologides A., Howe R. B., Kaplan M. E. Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma. Cancer Genet Cytogenet. 1984 Sep;13(1):17–28. doi: 10.1016/0165-4608(84)90084-0. [DOI] [PubMed] [Google Scholar]
  20. del Senno L., Aguiari G. L., Piva R. Dinucleotide repeat polymorphism in the human estrogen receptor (ESR) gene. Hum Mol Genet. 1992 Aug;1(5):354–354. doi: 10.1093/hmg/1.5.354. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES