Abstract
Paraffin sections from 30 human breast tissue specimens were stained with a specific antibody for thymosin beta-10, ATB10(38-43). The results showed that thymosin beta-10 was detected mainly in the malignant tissue, particularly in the cancerous cells, whereas the normal cell population around the lesions showed very weak staining. Also, the intensity of staining in the cancerous cells was proportionally increased with the increasing grade of the lesions.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cassimeris L., Safer D., Nachmias V. T., Zigmond S. H. Thymosin beta 4 sequesters the majority of G-actin in resting human polymorphonuclear leukocytes. J Cell Biol. 1992 Dec;119(5):1261–1270. doi: 10.1083/jcb.119.5.1261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodall G. J., Horecker B. L. Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence. Arch Biochem Biophys. 1987 Jul;256(1):402–405. doi: 10.1016/0003-9861(87)90461-9. [DOI] [PubMed] [Google Scholar]
- Hall A. K. Amplification-independent overexpression of thymosin beta-10 mRNA in human renal cell carcinoma. Ren Fail. 1994;16(2):243–254. doi: 10.3109/08860229409044864. [DOI] [PubMed] [Google Scholar]
- Hall A. K. Differential expression of thymosin genes in human tumors and in the developing human kidney. Int J Cancer. 1991 Jul 9;48(5):672–677. doi: 10.1002/ijc.2910480507. [DOI] [PubMed] [Google Scholar]
- Hall A. K., Hempstead J., Morgan J. I. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. Brain Res Mol Brain Res. 1990 Jul;8(2):129–135. doi: 10.1016/0169-328x(90)90057-k. [DOI] [PubMed] [Google Scholar]
- Hall A. K. Retinoic acid and serum modulation of thymosin beta-10 gene expression in rat neuroblastoma cells. J Mol Neurosci. 1991;2(4):229–237. [PubMed] [Google Scholar]
- Hannappel E., Xu G. J., Morgan J., Hempstead J., Horecker B. L. Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues. Proc Natl Acad Sci U S A. 1982 Apr;79(7):2172–2175. doi: 10.1073/pnas.79.7.2172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lin S. C., Morrison-Bogorad M. Developmental expression of mRNAs encoding thymosins beta 4 and beta 10 in rat brain and other tissues. J Mol Neurosci. 1990;2(1):35–44. doi: 10.1007/BF02896924. [DOI] [PubMed] [Google Scholar]
- Weterman M. A., van Muijen G. N., Ruiter D. J., Bloemers H. P. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. Int J Cancer. 1993 Jan 21;53(2):278–284. doi: 10.1002/ijc.2910530218. [DOI] [PubMed] [Google Scholar]
- Yu F. X., Lin S. C., Morrison-Bogorad M., Atkinson M. A., Yin H. L. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J Biol Chem. 1993 Jan 5;268(1):502–509. [PubMed] [Google Scholar]