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. 1991 Apr;173(8):2556–2561. doi: 10.1128/jb.173.8.2556-2561.1991

The RSF1 gene regulates septum formation in Saccharomyces cerevisiae.

L M Veinot-Drebot 1, G C Johnston 1, R A Singer 1
PMCID: PMC207820  PMID: 2013573

Abstract

Septum formation in the mitotic cell cycle of the budding yeast Saccharomyces cerevisiae occurs by conversion of the chitin ring, laid down at bud formation, into the primary septum. We show here that under certain conditions this septation is dependent on the newly identified RSF1 gene. However, cells harboring the rsf1-1 mutation accumulated in a postcytokinesis state, with delayed conversion of the chitin-rich annulus into the primary septum. This rsf1-1-mediated inhibition of septum formation only occurred under conditions of biosynthetic stress and was correlated with biosynthetically mediated inhibition of the cell-cycle regulatory step START. The RSF1 gene is distinct from the CHS2 chitin synthase gene that is responsible for septation, and thus RSF1 most likely encodes a regulator of chitin synthesis. We hypothesize that RSF1 activity facilitates septum formation during times of biosynthetic stress, to allow efficient septation even under these conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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