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. 1991 Aug;173(16):5244–5246. doi: 10.1128/jb.173.16.5244-5246.1991

Cysteine, even in low concentrations, induces transient amino acid starvation in Escherichia coli.

M A Sørensen 1, S Pedersen 1
PMCID: PMC208221  PMID: 1907268

Abstract

Cysteine, in concentrations down to 0.04 micrograms/ml, induces transient amino acid starvation in Escherichia coli growing in minimal medium. The duration depends on the concentration and is 5 min at 2 micrograms of cysteine per ml. At low cysteine concentrations, threonine and isoleucine almost completely abolish the starvation.

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Selected References

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  1. Hall B., Gallant J. Defective translation in RC - cells. Nat New Biol. 1972 May 31;237(74):131–135. doi: 10.1038/newbio237131a0. [DOI] [PubMed] [Google Scholar]
  2. Harris C. L. Cysteine and growth inhibition of Escherichia coli: threonine deaminase as the target enzyme. J Bacteriol. 1981 Feb;145(2):1031–1035. doi: 10.1128/jb.145.2.1031-1035.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Johnsen K., Molin S., Karlström O., Maaloe O. Control of protein synthesis in Escherichia coli: analysis of an energy source shift-down. J Bacteriol. 1977 Jul;131(1):18–29. doi: 10.1128/jb.131.1.18-29.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. O'Farrell P. H. The suppression of defective translation by ppGpp and its role in the stringent response. Cell. 1978 Jul;14(3):545–557. doi: 10.1016/0092-8674(78)90241-6. [DOI] [PubMed] [Google Scholar]
  5. Reeh S., Pedersen S., Friesen J. D. Biosynthetic regulation of individual proteins in relA+ and relA strains of Escherichia coli during amino acid starvation. Mol Gen Genet. 1976 Dec 22;149(3):279–289. doi: 10.1007/BF00268529. [DOI] [PubMed] [Google Scholar]
  6. Schleif R., Hess W., Finkelstein S., Ellis D. Induction kinetics of the L-arabinose operon of Escherichia coli. J Bacteriol. 1973 Jul;115(1):9–14. doi: 10.1128/jb.115.1.9-14.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Singer P. A., Levinthal M., Williams L. S. Synthesis of the isoleucyl- and valyl-tRNA synthetases and the isoleucine-valine biosynthetic enzymes in a threonine deaminase regulatory mutant of Escherichia coli K-12. J Mol Biol. 1984 May 5;175(1):39–55. doi: 10.1016/0022-2836(84)90444-3. [DOI] [PubMed] [Google Scholar]
  8. Sørensen M. A., Kurland C. G., Pedersen S. Codon usage determines translation rate in Escherichia coli. J Mol Biol. 1989 May 20;207(2):365–377. doi: 10.1016/0022-2836(89)90260-x. [DOI] [PubMed] [Google Scholar]

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