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. 1991 Sep;173(17):5551–5553. doi: 10.1128/jb.173.17.5551-5553.1991

Gyrase inhibitors increase the content of knotted DNA species of plasmid pBR322 in Escherichia coli.

S Ishii 1, T Murakami 1, K Shishido 1
PMCID: PMC208270  PMID: 1653211

Abstract

Treatment of Escherichia coli cells harboring pBR322 with the DNA gyrase inhibitors oxolinic acid and coumermycin A1 led to an increase in the content of knotted pBR322 molecules. This phenomenon was attributed to inhibition of gyrase-catalyzed unknotting of the plasmid DNA knotted by transcription.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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