Table.
Responses of striatal neurons to sensory stimuli and iv drug injections in rats in anesthetized and awake conditions during DA receptor blockade
| Awake, DA blockade | Urethane Anesthesia | |||||||
|---|---|---|---|---|---|---|---|---|
| Stimuli | + | NS | − | n | + | NS | − | n |
| Tail-touch | ||||||||
| cells (%) | 25 (73.5±7.6%) | 8 | 1 | 34 | 11 (26.8±6.9***) | 30 | 0 | 41 |
| tests (%) | 61 (69.3±4.9%) | 25 | 2 | 88 | 42 (42.0±4.9%***) | 57 | 1 | 100 |
| Tail-pinch | ||||||||
| cells (%) | 17 (77.3±8.9%) | 4 | 1 | 22 | 24 (46.1±6.9*) | 25 | 3 | 52 |
| tests (%) | 33 (71.7±6.6%) | 11 | 2 | 46 | 63 (50.4±4.5%**) | 56 | 6 | 125 |
| Cocaine HCl | ||||||||
| cells (%) | 14 (73.7±10.1%) | 5 | 0 | 19 | 5 (13.2±5.5***) | 33 | 0 | 38 |
| tests (%) | 32 (66.7±6.8%) | 15 | 1 | 48 | 24 (23.8±4.2%***) | 76 | 1 | 101 |
| Cocaine-M | ||||||||
| cells (%) | 9 (90.9±9.5%) | 1 | 0 | 10 | 4 (28.6±12.1**) | 9 | 1 | 14 |
| tests (%) | 24 (80.0±7.3%) | 6 | 0 | 30 | 5 (16.7±6.8%***) | 35 | 0 | 30 |
| Saline | ||||||||
| cells (%) | 3 (25.0±12.5%) | 9 | 0 | 12 | 3 (42.9±18.7) | 4 | 0 | 7 |
| tests (%) | 10 (31.3±8.2%) | 20 | 2 | 32 | 7 (36.8±11.1%) | 12 | 0 | 19 |
n, number of units and tests. +, − and NS are excitations, inhibitions and no responses. Asterisks show between-group differences in numbers of excitatory responses
**
p<0.01 and
***
p<0.001).