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. 1991 Nov;173(21):6651–6656. doi: 10.1128/jb.173.21.6651-6656.1991

Pathways for metabolism of ketoaldonic acids in an Erwinia sp.

S J Truesdell 1, J C Sims 1, P A Boerman 1, J L Seymour 1, R A Lazarus 1
PMCID: PMC209011  PMID: 1938871

Abstract

The pathways involved in the metabolism of ketoaldonic acids by Erwinia sp. strain ATCC 39140 have been investigated by use of a combination of enzyme assays and isolation of bacterial mutants. The catabolism of 2,5-diketo-D-gluconate (2,5-DKG) to gluconate can proceed by two separate NAD(P)H-dependent pathways. The first pathway involves the direct reduction of 2,5-DKG to 5-keto-D-gluconate, which is then reduced to gluconate. The second pathway involves the consecutive reduction of 2,5-DKG to 2-keto-L-gulonate and L-idonic acid, which is then oxidized to 5-keto-D-gluconate, which is then reduced to gluconate. Gluconate, which can also be produced by the NAD(P)H-dependent reduction of 2-keto-D-gluconate, is phosphorylated to 6-phosphogluconate and further metabolized through the pentose phosphate pathway. No evidence was found for the existence of the Entner-Doudoroff pathway in this strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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