| Primary pleural tumours |
|
| Angiosarcoma |
CD34, CD31, FVIIIRA |
| Epithelioid haemangioendothelioma |
CD34, CD31, FVIIIRA |
| Synovial sarcoma |
Cytokeratins, CD99, bcl‐2, cytogenetics |
| Sarcomas (various) |
Various depending on type |
| Localised malignant mesothelioma |
None |
| Solitary fibrous tumour |
CD34, bcl‐2, CD99 |
| Well‐differentiated papillary mesothelioma |
None (needs macroscopic appearance and usually peritoneum) |
| Adenomatoid tumour |
None (needs macroscopic appearance) |
| Calcifying tumour of the pleura |
None (usually young patient) |
| Desmoplastic small round cell tumour |
Cytokeratins, desmin, EMA, WT‐1, NSE |
| Thymic tumours |
Cytokeratins, EMA, occasionally CD5 |
| Lymphoma |
Lymphoid markers |
|
|
| Metastatic tumours |
|
| Carcinomas |
Cytokeratins |
| Sarcomas |
Various depending on type |
| Lymphomas |
Lymphoid markers |
| Malignant melanoma |
S‐100, HMB45, melan‐A |
| Thymic tumours |
Cytokeratins, EMA, occasionally CD5 |
|
|
| Non‐neoplastic mimics |
|
| Pleural fibrosis |
Rarely cytokeratins |
| Reactive mesothelial cells |
Desmin, EMA, p53 |
