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. 1989 Apr;171(4):2258–2261. doi: 10.1128/jb.171.4.2258-2261.1989

A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different developmental mutants.

D Stein 1, S N Cohen 1
PMCID: PMC209891  PMID: 2703474

Abstract

We report here the cloning of a Streptomyces lividans gene that when introduced on a multicopy plasmid vector reversed the pigment deficiency phenotype of several distinct mutants blocked in development, pigment production, or both. Although this gene was shown by restriction enzyme analysis to be similar to a previously cloned afsB-complementing gene of Streptomyces coelicolor, we show that it does not correspond to the S. coelicolor chromosomal locus designated afsB. Thus, the cloned locus, which we propose to rename afsR, appears to complement the AfsB- phenotype by pleiotropic regulatory effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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