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. 1989 May;171(5):2879–2881. doi: 10.1128/jb.171.5.2879-2881.1989

Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence.

A E Hromockyj 1, A T Maurelli 1
PMCID: PMC209979  PMID: 2651420

Abstract

Virulence in Shigella spp., as well as in strains of enteroinvasive Escherichia coli, is regulated by growth temperature. Previously, virR had been identified as the gene controlling the temperature-regulated expression of Shigella virulence. Since Shigella spp. and E. coli are also known to share greater than 90% DNA sequence homology, we sought to determine if nonpathogenic E. coli K-12 C600 contains a gene homologous to the Shigella flexneri 2a gene virR. Through the use of transduction and molecular cloning of strain C600 chromosomal DNA we have shown that E. coli K-12 does indeed contain a gene functionally homologous to the virR of S. flexneri.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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