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. 1989 Jun;171(6):3277–3281. doi: 10.1128/jb.171.6.3277-3281.1989

Role of homocysteine in metR-mediated activation of the metE and metH genes in Salmonella typhimurium and Escherichia coli.

M L Urbanowski 1, G V Stauffer 1
PMCID: PMC210046  PMID: 2656646

Abstract

The metR-mediated activation of the Salmonella typhimurium metE and metH genes was shown to be modulated by homocysteine, an intermediate in the methionine biosynthetic pathway. Homocysteine stimulates expression of a metE-lacZ gene fusion four- to fivefold by increasing transcription from the metE promoter. In contrast, homocysteine plays an inhibitory role in the metR-mediated activation of the metH gene, decreasing expression of a metH-lacZ gene fusion threefold.

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Selected References

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