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. 1989 Jun;171(6):3557–3559. doi: 10.1128/jb.171.6.3557-3559.1989

Overproduction of transposon Tn10-encoded tetracycline resistance protein results in cell death and loss of membrane potential.

B Eckert 1, C F Beck 1
PMCID: PMC210086  PMID: 2542231

Abstract

High-level expression of the Tn10 tetracycline resistance protein TetA in Escherichia coli caused partial collapse of the membrane potential, arrest of growth, and killing of the cells. Since alpha-methylglucoside transport was not affected, the overproduced TetA protein may cause not destruction of membrane structure but rather unrestricted translocation of protons and/or ions across the membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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