Abstract
Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10-4 µl CO2 per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contrast, in the surrounding glia the anaerobic glycolysis increased and the respiratory enzyme activity decreased, suggesting a Crabtree effect. The evidence is discussed for a regulatory metabolic mechanism operating between the neuron and its glia. Hypoxia of 8 per cent O2 caused an increase of both oxygen consumption and CO2 production in the nerve cells, but did not change the glia values.
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Selected References
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