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. 1990 Dec;172(12):7260–7262. doi: 10.1128/jb.172.12.7260-7262.1990

DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.

S Sreedharan 1, M Oram 1, B Jensen 1, L R Peterson 1, L M Fisher 1
PMCID: PMC210851  PMID: 2174869

Abstract

The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine----leucine) and/or codon 85 (serine----proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83----leucine and alanine 84----proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in resistance to ciprofloxacin in S. aureus.

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Selected References

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