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. 1973 Apr 1;57(1):124–132. doi: 10.1083/jcb.57.1.124

GROWTH OF NORMAL AND TRANSFORMED RAT EMBRYO FIBROBLASTS

Effects of Glycolipids from Salmonella minnesota R Mutants

C Brailovsky 1, M Trudel 1, R Lallier 1, V N Nigam 1
PMCID: PMC2108955  PMID: 4347975

Abstract

Addition of glycolipids obtained from Salmonella minnesota R mutants to normal, spontaneously transformed, and SV40-transformed rat embryo fibroblasts in culture results in an inhibition of growth of transformed cells but not of normal cells. In the presence of the glycolipid with the smallest carbohydrate chain length, spontaneously transformed cells stop growing when they reach confluency. Inhibition of growth of transformed cells is inversely related to the chain length of the core sugars. Glycolipid mR595 is shown to bind with the cell membrane of transformed cells and elicits an augmentation in the intracellular level of cyclic AMP. Normal cells bind relatively less glycolipid mR595 and show a lower percent of increase in cyclic AMP due to glycolipid mR595 than do transformed cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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