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. 1973 May 1;57(2):397–405. doi: 10.1083/jcb.57.2.397

GROWTH INHIBITION OF MURINE TUMOR CELLS, IN VITRO, BY PUROMYCIN, [6N]O2'-DIBUTYRYL 3',5'-ADENOSINE MONOPHOSPHATE, OR ADENOSINE

Evidence of Commitment for Cell Division

D B Thomas 1, Gay Medley 1, C A Lingwood 1
PMCID: PMC2108970  PMID: 4348788

Abstract

The cytostatic effects of puromycm, [6N]O2'-dibutyryl 3',5'-adenosine monophosphate, and adenosine on asynchronous and synchronous cultures of the murine mastocytoma, P815Y, have been studied. Cell growth was arrested after a minimum of one further division. A model is proposed for the inhibition of cell division in which the periods of inhibition and growth arrest are separated in time by one cell cycle.

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Selected References

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