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. 1988 Mar;170(3):1275–1278. doi: 10.1128/jb.170.3.1275-1278.1988

A clinical isolate of transposon Tn5 expressing streptomycin resistance in Escherichia coli.

O Genilloud 1, J Blázquez 1, P Mazodier 1, F Moreno 1
PMCID: PMC210903  PMID: 2830233

Abstract

The central region of transposon Tn5 carries three antibiotic resistance markers: neo, ble, and str. The str gene codes for a phosphotransferase that inactivates streptomycin. This activity is phenotypically expressed in several gram-negative bacteria but not in Escherichia coli. We identified a Tn5 variant in E. coli clinical isolates that express streptomycin resistance. This transposon carries a 6-base-pair deletion within the str gene, near the 3' end. The same kind of mutation had been previously obtained experimentally from Tn5.

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Selected References

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