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. 1975 Mar 1;64(3):551–556. doi: 10.1083/jcb.64.3.551

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential

PMCID: PMC2109544  PMID: 1150745

Abstract

Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in heteropolykaryons was a function of the ratio of HeLa to senescent nuclei.

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Selected References

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