Table 3 Blood differential cell count and TNFα level.
| Control subjects | COPD patients | |||
|---|---|---|---|---|
| Non‐smoking | Smoking | Steroid free | Steroid treated | |
| (n = 11) | (n = 10) | (n = 10) | (n = 8) | |
| Leucocytes (×106/ml) | 5.7 (4.4–8.7) | 7.2 (4.6–10.4) | 9.1 (7.1–13.9)*† | 8.7 (6.1–16.8)*† |
| Neutrophils | ||||
| % | 49.6 (44.4–73.0) | 57.1 (45.4–70.8) | 61.8 (49.9–68.4)* | 69.9 (54.3–85.5)*† |
| ×106/ml | 3.3 (2.13–5.5) | 4.1 (2.1–6.4) | 5.9 (3.6–8.7)* | 6.7 (3.7–13.6)*† |
| Lymphocytes | ||||
| % | 36.5 (17.8–42.7) | 32.6 (18.8–39.9) | 27.3 (19.8–39.9)* | 20.4 (9.1–33.7)*† |
| ×106/ml | 2.1 (1.3–3.5) | 2.0 (1.3–3.3) | 2.6 (1.5–3.7) | 1.8 (0.8–2.7) |
| Monocytes | ||||
| % | 5.7 (4.1–9.9) | 6.3 (3.5–8.7) | 6.4 (4.3–8.1) | 5.6 (3.3–8.7) |
| ×106/ml | 0.4 (0.3–0.7) | 0.4 (0.3–0.6) | 0.6 (0.3–1.1)*† | 0.5 (0.3–1.0) |
| Eosinophils | ||||
| % | 2.4 (0.9–4.2) | 1.7 (0.6–4.1) | 2.5 (0.8–7.6) | 1.7 (0.0–7.8) |
| ×106/ml | 0.1 (0.1–0.3) | 0.1 (0.1–0.3) | 0.2 (0.1–0.5) | 0.2 (0.0–0.9) |
| Basophils | ||||
| % | 0.7 (0.4–1.0) | 0.7 (0.4–1.3) | 0.6 (0.3–0.9) | 0.4 (0.0–1.2) |
| ×106/ml | 0.04 (0.02–0.06) | 0.05 (0.02–0.07) | 0.05 (0.03–0.1) | 0.03 (0.0–0.14) |
| TNFα (pg/ml) | 3.5 (1.7–9.6) | 3.4 (2.6–3.7) | 3.8 (2.5–6.1) | 3.6 (2.5–4.9) |
Values are expressed as median (range).
Differences between groups were tested using the Kruskal‐Wallis H test and, if appropriate (p<0.05), subsequent analysis of subgroups was performed by the Mann‐Whitney U test.
*p<0.05 v non‐smoking controls; †p<0.05 v smoking controls.