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. 1988 Jun;170(6):2537–2542. doi: 10.1128/jb.170.6.2537-2542.1988

Isolation and characterization of a UV-sensitive mutator (mutB1) mutant of Haemophilus influenzae.

R B Walter 1, J H Stuy 1
PMCID: PMC211168  PMID: 3259573

Abstract

The mutB1 mutant of Haemophilus influenzae is very sensitive to UV radiation but only slightly sensitive to methylmethane sulfonate or N-methyl-N'-nitro-N-nitrosoguanidine. Cultures of mutB1 cells contain high numbers of spontaneous mutants and show hypermutability after exposure to the latter mutagen. Normally high-efficiency transforming markers, as well as low-efficiency ones, transform mutB1 recipients at similarly low efficiencies. Significant host cell reactivation was observed when mutB1 cells were exposed to UV-damaged phage; however, these mutants showed a decrease in phage recombination. This mutant did not degrade its DNA following exposure to UV. It is speculated that the mutB1 mutation is similar to the Escherichia coli uvrD mutation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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