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. 1981 Jun 1;89(3):680–683. doi: 10.1083/jcb.89.3.680

Effect of tau on the vinblastine-induced aggregation of tubulin

PMCID: PMC2111808  PMID: 6788779

Abstract

Two microtubule-associated proteins, tau and the high molecular weight microtubule-associated protein 2 (MAP 2), were purified from rat brain microtubules. Addition of either protein to pure tubulin caused microtubule assembly. In the presence of tau and 10 microM vinblastine, tubulin aggregated into spiral structures. If tau was absent, or replaced by MAP 2, little aggregation occurred in the presence of vinblastine. Thus, vinblastine may be a useful probe in elucidating the individual roles of tau and MAP 2 in microtubule assembly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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