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. 1981 Sep 1;90(3):727–731. doi: 10.1083/jcb.90.3.727

Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight

PMCID: PMC2111890  PMID: 7197280

Abstract

The tumor promoter, phorbol myristate acetate (PMA), stimulates plasminogen activator production and extracellular release in confluent Swiss 3T3 cells. Coordinated with the increased extracellular release is a redistribution of the activity into plasma membrane-enriched fractions and a shift in the predominant molecular weight species from 75,000 to 49,000 daltons. The evidence suggests that PMA induces the formation of the 49,000 dalton species which is preferentially located in plasma membrane-enriched fractions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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