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. 1983 Apr 1;96(4):1117–1119. doi: 10.1083/jcb.96.4.1117

Transport and cleavage of bacterial pre-β-lactamase by mammalian microsomes

HM Kronenberg, BJ Fennick, TJ Vasicek
PMCID: PMC2112328  PMID: 6300144

Abstract

Eucaryotic endoplasmic reticulum and bacterial inner cell membranes use strikingly similar mechanisms to transport proteins from one cellular compartment to another. Using a mammalian linked transcription-translation system, we show here that canine pancreatic microsomes accurately cleave off the signal sequence of β-lactamase, a secreted bacterial protein. We suggest that the apparent differences between bacterial and eukaryotic protein transport may involve only minor modulations of a profoundly conserved mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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