Abstract
Peptides that stimulate astroglial proliferation are produced in traumatized adult rat brain by 10 d after injury. These same peptides are released by ameboid microglia activated in vitro. Our findings suggest that astroglial scarring is regulated in part by the release of factors from ameboid microglia near the site of brain injury.
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Selected References
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- Aguayo A. J., David S., Bray G. M. Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J Exp Biol. 1981 Dec;95:231–240. doi: 10.1242/jeb.95.1.231. [DOI] [PubMed] [Google Scholar]
- Bottenstein J. E., Sato G. H. Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci U S A. 1979 Jan;76(1):514–517. doi: 10.1073/pnas.76.1.514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Böhlen P., Stein S., Dairman W., Udenfriend S. Fluorometric assay of proteins in the nanogram range. Arch Biochem Biophys. 1973 Mar;155(1):213–220. doi: 10.1016/s0003-9861(73)80023-2. [DOI] [PubMed] [Google Scholar]
- Giulian D., Iwanij V. The response of optic tract glia during regeneration of the goldfish visual system. II. Tectal factors stimulate optic tract glia. Brain Res. 1985 Jul 22;339(1):97–104. doi: 10.1016/0006-8993(85)90625-0. [DOI] [PubMed] [Google Scholar]
- Giulian D., Lachman L. B. Interleukin-1 stimulation of astroglial proliferation after brain injury. Science. 1985 Apr 26;228(4698):497–499. doi: 10.1126/science.3872478. [DOI] [PubMed] [Google Scholar]
- Giulian D. Peptides from the regenerating central nervous system of goldfish stimulate glia. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3567–3571. doi: 10.1073/pnas.81.11.3567. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giulian D., Tomozawa Y., Hindman H., Allen R. L. Peptides from regenerating central nervous system promote specific populations of macroglia. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4287–4290. doi: 10.1073/pnas.82.12.4287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCarthy K. D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol. 1980 Jun;85(3):890–902. doi: 10.1083/jcb.85.3.890. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silver J., Lorenz S. E., Wahlsten D., Coughlin J. Axonal guidance during development of the great cerebral commissures: descriptive and experimental studies, in vivo, on the role of preformed glial pathways. J Comp Neurol. 1982 Sep 1;210(1):10–29. doi: 10.1002/cne.902100103. [DOI] [PubMed] [Google Scholar]
- Singer M., Nordlander R. H., Egar M. Axonal guidance during embryogenesis and regeneration in the spinal cord of the newt: the blueprint hypothesis of neuronal pathway patterning. J Comp Neurol. 1979 May 1;185(1):1–21. doi: 10.1002/cne.901850102. [DOI] [PubMed] [Google Scholar]