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. 1989 Apr 1;108(4):1187–1194. doi: 10.1083/jcb.108.4.1187

Intestinal epithelial differentiation: new insights from chimeric and transgenic mice

PMCID: PMC2115507  PMID: 2647764

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Selected References

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  1. Al-Nafussi A. I., Wright N. A. Cell kinetics in the mouse small intestine during immediate postnatal life. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982;40(1):51–62. doi: 10.1007/BF02932850. [DOI] [PubMed] [Google Scholar]
  2. Allen N. D., Cran D. G., Barton S. C., Hettle S., Reik W., Surani M. A. Transgenes as probes for active chromosomal domains in mouse development. Nature. 1988 Jun 30;333(6176):852–855. doi: 10.1038/333852a0. [DOI] [PubMed] [Google Scholar]
  3. Bjerknes M., Cheng H. The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am J Anat. 1981 Jan;160(1):51–63. doi: 10.1002/aja.1001600105. [DOI] [PubMed] [Google Scholar]
  4. Bjerknes M., Cheng H. The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse. Am J Anat. 1981 Jan;160(1):77–91. doi: 10.1002/aja.1001600107. [DOI] [PubMed] [Google Scholar]
  5. Bos J. L., Fearon E. R., Hamilton S. R., Verlaan-de Vries M., van Boom J. H., van der Eb A. J., Vogelstein B. Prevalence of ras gene mutations in human colorectal cancers. 1987 May 28-Jun 3Nature. 327(6120):293–297. doi: 10.1038/327293a0. [DOI] [PubMed] [Google Scholar]
  6. Cheng H., Leblond C. P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anat. 1974 Dec;141(4):461–479. doi: 10.1002/aja.1001410403. [DOI] [PubMed] [Google Scholar]
  7. Cheng H., Leblond C. P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat. 1974 Dec;141(4):537–561. doi: 10.1002/aja.1001410407. [DOI] [PubMed] [Google Scholar]
  8. Dharmsathaphorn K., McRoberts J. A., Mandel K. G., Tisdale L. D., Masui H. A human colonic tumor cell line that maintains vectorial electrolyte transport. Am J Physiol. 1984 Feb;246(2 Pt 1):G204–G208. doi: 10.1152/ajpgi.1984.246.2.G204. [DOI] [PubMed] [Google Scholar]
  9. Elmes M. E., Stanton M. R., Howells C. H., Lowe G. H. Relation between the mucosal flora and Paneth cell population of human jejunum and ileum. J Clin Pathol. 1984 Nov;37(11):1268–1271. doi: 10.1136/jcp.37.11.1268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Erlandsen S. L., Chase D. G. Paneth cell function: phagocytosis and intracellular digestion of intestinal microorganisms. I. Hexamita muris. J Ultrastruct Res. 1972 Nov;41(3):296–318. doi: 10.1016/s0022-5320(72)90071-8. [DOI] [PubMed] [Google Scholar]
  11. Ferguson A., Gerskowitch V. P., Russell R. I. Pre- and postweaning disaccharidase patterns in isografts of fetal mouse intestine. Gastroenterology. 1973 Feb;64(2):292–297. [PubMed] [Google Scholar]
  12. Forrester K., Almoguera C., Han K., Grizzle W. E., Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. 1987 May 28-Jun 3Nature. 327(6120):298–303. doi: 10.1038/327298a0. [DOI] [PubMed] [Google Scholar]
  13. Hediger M. A., Coady M. J., Ikeda T. S., Wright E. M. Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. 1987 Nov 26-Dec 2Nature. 330(6146):379–381. doi: 10.1038/330379a0. [DOI] [PubMed] [Google Scholar]
  14. Hooper N. M., Low M. G., Turner A. J. Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C. Biochem J. 1987 Jun 1;244(2):465–469. doi: 10.1042/bj2440465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hooper N. M., Turner A. J. Ectoenzymes of the kidney microvillar membrane. Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety. FEBS Lett. 1988 Mar 14;229(2):340–344. doi: 10.1016/0014-5793(88)81152-9. [DOI] [PubMed] [Google Scholar]
  16. Huet C., Sahuquillo-Merino C., Coudrier E., Louvard D. Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation. J Cell Biol. 1987 Jul;105(1):345–357. doi: 10.1083/jcb.105.1.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hunziker W., Spiess M., Semenza G., Lodish H. F. The sucrase-isomaltase complex: primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein. Cell. 1986 Jul 18;46(2):227–234. doi: 10.1016/0092-8674(86)90739-7. [DOI] [PubMed] [Google Scholar]
  18. Jolma V. M., Kendall K., Koldovský O. Differences in the development of jejunum and ileum as observed in fetal rat isografts. Possible implications related to the villus size gradient. Am J Anat. 1980 Jun;158(2):211–215. doi: 10.1002/aja.1001580209. [DOI] [PubMed] [Google Scholar]
  19. Kendall K., Jumawan J., Koldovský O. Development of jejunoileal differences of activity of lactase, sucrase and acid beta-galactosidase in isografts of fetal rat intestine. Biol Neonate. 1979;36(3-4):206–214. doi: 10.1159/000241229. [DOI] [PubMed] [Google Scholar]
  20. Li E., Locke B., Yang N. C., Ong D. E., Gordon J. I. Characterization of rat cellular retinol-binding protein II expressed in Escherichia coli. J Biol Chem. 1987 Oct 5;262(28):13773–13779. [PubMed] [Google Scholar]
  21. Lisanti M. P., Sargiacomo M., Graeve L., Saltiel A. R., Rodriguez-Boulan E. Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9557–9561. doi: 10.1073/pnas.85.24.9557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Low M. G. Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors. Biochem J. 1987 May 15;244(1):1–13. doi: 10.1042/bj2440001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Lowe J. B., Sacchettini J. C., Laposata M., McQuillan J. J., Gordon J. I. Expression of rat intestinal fatty acid-binding protein in Escherichia coli. Purification and comparison of ligand binding characteristics with that of Escherichia coli-derived rat liver fatty acid-binding protein. J Biol Chem. 1987 Apr 25;262(12):5931–5937. [PubMed] [Google Scholar]
  24. Madara J. L., Dharmsathaphorn K. Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol. 1985 Dec;101(6):2124–2133. doi: 10.1083/jcb.101.6.2124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Mantei N., Villa M., Enzler T., Wacker H., Boll W., James P., Hunziker W., Semenza G. Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. EMBO J. 1988 Sep;7(9):2705–2713. doi: 10.1002/j.1460-2075.1988.tb03124.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Mathan M., Moxey P. C., Trier J. S. Morphogenesis of fetal rat duodenal villi. Am J Anat. 1976 May;146(1):73–92. doi: 10.1002/aja.1001460104. [DOI] [PubMed] [Google Scholar]
  27. Montgomery R. K., Sybicki M. A., Grand R. J. Autonomous biochemical and morphological differentiation in fetal rat intestine transplanted at 17 and 20 days of gestation. Dev Biol. 1981 Oct 15;87(1):76–84. doi: 10.1016/0012-1606(81)90062-2. [DOI] [PubMed] [Google Scholar]
  28. Palmiter R. D., Behringer R. R., Quaife C. J., Maxwell F., Maxwell I. H., Brinster R. L. Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell. 1987 Jul 31;50(3):435–443. doi: 10.1016/0092-8674(87)90497-1. [DOI] [PubMed] [Google Scholar]
  29. Phillips T. E., Huet C., Bilbo P. R., Podolsky D. K., Louvard D., Neutra M. R. Human intestinal goblet cells in monolayer culture: characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line. Gastroenterology. 1988 Jun;94(6):1390–1403. doi: 10.1016/0016-5085(88)90678-6. [DOI] [PubMed] [Google Scholar]
  30. Ponder B. A., Schmidt G. H., Wilkinson M. M., Wood M. J., Monk M., Reid A. Derivation of mouse intestinal crypts from single progenitor cells. Nature. 1985 Feb 21;313(6004):689–691. doi: 10.1038/313689a0. [DOI] [PubMed] [Google Scholar]
  31. Ponder B. A., Wilkinson M. M. Organ-related differences in binding of Dolichos biflorus agglutinin to vascular endothelium. Dev Biol. 1983 Apr;96(2):535–541. doi: 10.1016/0012-1606(83)90191-4. [DOI] [PubMed] [Google Scholar]
  32. Ponder B. A., Wilkinson M. M., Wood M. H-2 antigens as markers of cellular genotype in chimaeric mice. J Embryol Exp Morphol. 1983 Aug;76:83–93. [PubMed] [Google Scholar]
  33. Rodewald R., Abrahamson D. R. Receptor-mediated transport of IgG across the intestinal epithelium of the neonatal rat. Ciba Found Symp. 1982;(92):209–232. doi: 10.1002/9780470720745.ch11. [DOI] [PubMed] [Google Scholar]
  34. Rombout J. H., van der Grinten C. P., Binkhorst F. M., Taverne-Thiele J. J., Schooneveld H. Immunocytochemical identification and localization of peptide hormones in the gastro-entero-pancreatic (GEP) endocrine system of the mouse and a stomachless fish, Barbus conchonius. Histochemistry. 1986;84(4-6):471–483. doi: 10.1007/BF00482980. [DOI] [PubMed] [Google Scholar]
  35. Rubin D. C., Ong D. E., Gordon J. I. Cellular differentiation in the emerging fetal rat small intestinal epithelium: mosaic patterns of gene expression. Proc Natl Acad Sci U S A. 1989 Feb;86(4):1278–1282. doi: 10.1073/pnas.86.4.1278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Satoh Y., Ishikawa K., Ono K., Vollrath L. Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats. Digestion. 1986;34(2):115–121. doi: 10.1159/000199319. [DOI] [PubMed] [Google Scholar]
  37. Satoh Y., Vollrath L. Quantitative electron microscopic observations on Paneth cells of germfree and ex-germfree Wistar rats. Anat Embryol (Berl) 1986;173(3):317–322. doi: 10.1007/BF00318915. [DOI] [PubMed] [Google Scholar]
  38. Schmidt G. H., Garbutt D. J., Wilkinson M. M., Ponder B. A. Clonal analysis of intestinal crypt populations in mouse aggregation chimaeras. J Embryol Exp Morphol. 1985 Feb;85:121–130. [PubMed] [Google Scholar]
  39. Schmidt G. H., Ponder B. A. From patterns to clones in chimaeric tissues. Bioessays. 1987 Mar;6(3):104–108. doi: 10.1002/bies.950060303. [DOI] [PubMed] [Google Scholar]
  40. Schmidt G. H., Wilkinson M. M., Ponder B. A. A method for the preparation of large intact sheets of intestinal mucosa: application to the study of mouse aggregation chimeras. Anat Rec. 1984 Oct;210(2):407–411. doi: 10.1002/ar.1092100216. [DOI] [PubMed] [Google Scholar]
  41. Schmidt G. H., Wilkinson M. M., Ponder B. A. Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras. Cell. 1985 Feb;40(2):425–429. doi: 10.1016/0092-8674(85)90156-4. [DOI] [PubMed] [Google Scholar]
  42. Schmidt G. H., Winton D. J., Ponder B. A. Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. Development. 1988 Aug;103(4):785–790. doi: 10.1242/dev.103.4.785. [DOI] [PubMed] [Google Scholar]
  43. Smith M. W., Jarvis L. G. Use of differential interference contrast microscopy to determine cell renewal times in mouse intestine. J Microsc. 1980 Feb;118(2):153–159. doi: 10.1111/j.1365-2818.1980.tb00258.x. [DOI] [PubMed] [Google Scholar]
  44. Sweetser D. A., Birkenmeier E. H., Hoppe P. C., McKeel D. W., Gordon J. I. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Genes Dev. 1988 Oct;2(10):1318–1332. doi: 10.1101/gad.2.10.1318. [DOI] [PubMed] [Google Scholar]
  45. Sweetser D. A., Hauft S. M., Hoppe P. C., Birkenmeier E. H., Gordon J. I. Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9611–9615. doi: 10.1073/pnas.85.24.9611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Sweetser D. A., Heuckeroth R. O., Gordon J. I. The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function. Annu Rev Nutr. 1987;7:337–359. doi: 10.1146/annurev.nu.07.070187.002005. [DOI] [PubMed] [Google Scholar]
  47. Uiterdijk H. G., Ponder B. A., Festing M. F., Hilgers J., Skow L., Van Nie R. The gene controlling the binding sites of Dolichos biflorus agglutinin, Dlb-1, is on chromosome 11 of the mouse. Genet Res. 1986 Apr;47(2):125–129. doi: 10.1017/s0016672300022953. [DOI] [PubMed] [Google Scholar]
  48. Vogelstein B., Fearon E. R., Hamilton S. R., Kern S. E., Preisinger A. C., Leppert M., Nakamura Y., White R., Smits A. M., Bos J. L. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988 Sep 1;319(9):525–532. doi: 10.1056/NEJM198809013190901. [DOI] [PubMed] [Google Scholar]
  49. Wilson J. M., Whitney J. A., Neutra M. R. Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum. J Cell Biol. 1987 Aug;105(2):691–703. doi: 10.1083/jcb.105.2.691. [DOI] [PMC free article] [PubMed] [Google Scholar]

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