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. 1990 Apr 1;110(4):955–961. doi: 10.1083/jcb.110.4.955

Fatty acylation promotes fusion of transport vesicles with Golgi cisternae

PMCID: PMC2116082  PMID: 2324202

Abstract

Two different methods, stimulation of transport by fatty acyl-coenzyme A (CoA) and inhibition of transport by a nonhydrolyzable analogue of palmitoyl-CoA, reveal that fatty acylation is required to promote fusion of transport vesicles with Golgi cisternae. Specifically, fatty acyl-CoA is needed after the attachment of coated vesicles and subsequent uncoating of the vesicles, and after the binding of the NEM- sensitive fusion protein (NSF) to the membranes, but before the actual fusion event. We therefore suggest that an acylated transport component participates, directly or indirectly, in membrane fusion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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