Prevalence and pattern of perceived intelligibility changes in Parkinson's disease

Abstract

Background

Changes to spoken communication are inevitable in Parkinson's disease (PD). It remains unclear what consequences changes have for intelligibility of speech.

Aims

To establish the prevalence of impaired speech intelligibility in people with PD and the relationship of intelligibility decline to indicators of disease progression.

Methods

125 speakers with PD and age matched unaffected controls completed a diagnostic intelligibility test and described how to carry out a common daily activity in an “off drug” state. Listeners unfamiliar with dysarthric speech evaluated responses.

Results

69.6% (n = 87) of people with PD fell below the control mean of unaffected speakers (n = 40), 51.2% (n = 64) by more than −1 SD below. 48% (n = 60) were perceived as worse than the lowest unaffected speaker for how disordered speech sounded. 38% (n = 47) placed speech changes among their top four concerns regarding their PD. Intelligibility level did not correlate significantly with age or disease duration and only weakly with stage and severity of PD. There were no significant differences between participants with tremor dominant versus postural instability/gait disorder motor phenotypes of PD.

Conclusions

Speech intelligibility is significantly reduced in PD; it can be among the main concerns of people with PD, but it is not dependent on disease severity, duration or motor phenotype. Patients' own perceptions of the extent of change do not necessarily reflect objective measures.

Voice and speech changes are inevitable in Parkinson's disease (PD) as the condition progresses.¹,² The consequences of these changes for intelligibility and acceptability of spoken communication are unclear.

Previous surveys³,⁴,⁵,⁶ estimate 70–90% of patients with PD present with voice changes, 45–55% with speech changes. Only Coates and Bakheit⁶ focused directly on intelligibility, determining 65% of 48 participants had problems. This study had several drawbacks, including lack of control recordings, grading of intelligibility by a single speech language therapist and failure to match word lists presented to different speakers.

We assessed a large sample of people with PD using a diagnostic intelligibility test⁷,⁸ with evaluation of responses by listeners with no professional or personal experience of listening to disordered speech or association with PD. We compared results of PD subjects to an age matched control group and in relation to a variety of indicators of disease progression.

Methods

Participants

We recruited subjects from a community and hospital acquired cohort of patients⁹,¹⁰ meeting UK Parkinson's Disease Society Brain Bank Criteria for PD.¹¹ Individuals were excluded if they had a history of speech–language disorder prior to PD symptoms onset, comorbidity associated with speech changes, did not speak English or did not wish to join the study.

Friends and family members of individuals with PD involved in the study participated as control speakers. Volunteers with a history of neurological disorder, speech–language problems or English as a second language were excluded.

The study was approved by the Sunderland Research Ethics Committee.

Assessment

Participants were assessed first thing in the morning, at home, with antiparkinsonian therapy withheld and fasting since midnight. A practically defined “off state” Unified Parkinson's Disease Rating Scale (UPDRS),¹² Hoehn and Yahr rating,¹³ cognitive testing¹⁴ and depression rating¹⁵ were performed approximately 2 weeks prior to speech testing. Motor phenotype (tremor dominant, posture and gait instability or indeterminate) was derived from the UPDRS score.¹⁶

Materials and procedure

The intelligibility measure was a 60 item test based on Yorkston et al.⁸ Six matched minimally differing word lists were created. Participants read one of these systematically rotated lists with words appearing singly on a computer screen, the rate dictated by the speaker. Six further parallel lists of foils were devised. Responses were digitally recorded, utilising a constant recording level (Marantz Professional PMD690) with an AKG (C420) head mounted microphone. Control speaker intelligibility testing took place under identical circumstances.

Intelligibility rating

Listeners (blind to any speaker or word list variables) scored the de‐noised and cleaned recordings, circling from 12 options (see samples in the appendix) the word they thought they heard. On sentence items, listeners checked only the varying word. Items were played one at a time and heard only once. Control speaker scores provided norm references for judgements on severity of intelligibility impairment.

Listeners

Following standard practice,⁷,⁸ to minimise listener variability effects¹⁷,¹⁸ and overestimation of scores through familiarity with word lists,¹⁹ three listeners scored each speaker independently; each listener heard only five tracks; and grouping of listeners was systematically varied to avoid the same trio evaluating successive tracks. Raters had no prior experience of PD or listening to disordered speech. The final score was the mean total words correctly identified across the three listeners. The 99 listeners (mean age 40.5 (SD 20.96) years, range 18–83) required for the 125 patient and 40 control recordings using this procedure received a £5 (approximately Euros 7.50; US$ 9.50) store voucher.

Perceived disorderedness of speech

People with PD and control speakers described how to make a cup of tea. Listeners rated whether “this person has a problem with spoken communication” on a 5 point scale (1 strongly agree; 5 strongly disagree). The 5–10 s recording excerpts contained no inappropriate pauses, restarts or word retrieval gaps.

At assessment, PD subjects rated whether “My voice is not as good as it used to be”; “When I speak sounds come out slurred and unclear”; “I am happy with my speech as it is now” on 5 point scales from strongly agree to strongly disagree. They ranked where speech changes came in relation to other concerns associated with their PD.

Statistical analysis was carried out via SPSS for Windows 14.0. Non‐parametric methods (Mann–Whitney for two independent groups, Kruskal–Wallis test for more than two independent groups, χ² test and Spearman's rho) were used to investigate the non‐normally distributed data.

Results

We recruited 176 subjects with PD potentially agreeing to join a study. They were younger than those not agreeing (mean age 70.2 years vs 77.0 years, Mann–Whitney p<0.001) and less likely to be living in residential or nursing care (χ², p<0.001).⁹,¹⁰ A total of 140 agreed to participate in this study. Complete intelligibility tests were obtained from 125 individuals (table 1). Fifteen were incomplete because of visual acuity or reading difficulties or because of technical problems with sound recordings. Mann–Whitney comparisons indicated no significant differences in age, disease duration, Hoehn and Yahr stage or UPDRS II and III totals between the 125 participants and 51 individuals without an intelligibility score.

Table 1 Age and disease specific details for the 125 participants with Parkinson's disease.

	Mean	median	SD	Range (IQR)
Age (y)	71.5	73	8.6	45–91
Time since diagnosis (y)	8.12	5	6.9	1–38 (IQR 3–11)
Hoehn & Yahr stage (max 5 severe)	2.5	2.5	0.88	1–5 (IQR 2–3)
UPDRS II (max 52 severe)	14.6	15	6.4	1–33
UPDRS III (max 108 severe)	34.5	34	14.9	8–73
MMSE14 (⩾23 normal)	25.3	27	3.7	14–30 (IQR 23–28)
GDS15 (⩽4 normal)	4.8	4	3.3	0–14 (IQR 2–7)

GDS, Geriatric Depression Scale; MMSE, Mini‐Mental State Examination; UPDRS, Unified Parkinson's Disease Rating Scale.

Forty family members and friends of participants with PD (mean age 70.2 (SD 8) years; 21 female) were recruited as control speakers for the intelligibility test. Fifty‐seven further subjects (mean age 57.9 years; median 64; range 23–87) were recorded describing “how to make a cup of tea” to provide control data for listener perceptions of disorderedness of speech.

Intelligibility

Listeners recognised a mean of 49.6 words from the PD group (SD 7.0) compared with 54.6 words (SD 3.6) from controls (Mann–Whitney, p<0.001); 69.6% (n = 87) of people with PD fell below the control mean (51.2% (n = 64) >−1 SD below).

Significant, albeit only moderate, Spearman's correlations existed between intelligibility scores and Hoehn and Yahr stage (r = −0.263, p = 0.003); UPDRS II (r = −0.4, p<0.001) and UPDRS III (r = −0.40, p<0.001); and cognition¹⁴ score (r = 0.317, p<0.001). Age showed a borderline significant association with intelligibility (r = −0.167, p = 0.06), while time since diagnosis (r = −0.020, p = 0.81), duration of treatment (r = −0.058, p = 0.542) and depression rating (r = −0.157, p = 0.82) did not.

A linear regression model was constructed to examine the effect of age, gender, disease duration, stage,¹²,¹³ cognitive status (Mini‐Mental State Examination (MMSE)¹⁴) and depression¹⁵ on intelligibility. Best fit was obtained with UPDRS III and MMSE (R² = 0.217, adjusted R² = 0.204). There was no significant difference between motor phenotypes by intelligibility scores (Kruskal–Wallis test, p = 0.36). Tremor dominant (n = 38) and postural instability (n = 62) subtypes also did not differ significantly (Mann–Whitney, p = 0.18).

Disorderedness ratings

The median rating for PD subjects was 3 (IQR 2–3) compared with a median rating of 4 (IQR 3–5) for control speakers (Mann–Whitney, p<0.001). Forty‐eight per cent (n = 60) of people with PD were rated as worse than the poorest control speaker.

Self‐perception ratings

Seventy‐six per cent of the PD group felt their voice was not as good as it used to be; 56.5% reported their speech was slurred. Only 4.2% reported no speech–language changes, although 18.1% were happy with how they spoke. Ten per cent of PD subjects rated speech–voice changes as their number one concern regarding changes associated with PD; 38% placed speech among their top four concerns.

Discussion

This study demonstrates that listeners find more than 50% of PD subjects difficult to understand and 38% of patients with PD rate speech difficulties as a major concern. Speech intelligibility is not, however, strongly associated with PD motor phenotype or measures of disease severity. Several possibilities may account for the latter.

The proportion of participants in Hoehn and Yahr stages 1–1.5 and 4–5 was relatively low compared with other stages, although representative of patterns in other studies.²⁰ Acquisition bias towards mild–moderate disease severity may have masked a possible association, while fluctuation in motor state related to the time between motor and speech assessments could have contributed. Measures of limb and axial motor involvement may not necessarily reflect changes in speech motor control.²¹,²² Intelligibility represents what the speech control processes can achieve employing all possible compensatory tactics. It also reflects listener effort. The latter effects might account for the apparent lack of deterioration in intelligibility in the early phases of PD.

Intelligibility tests may overestimate the size of the problem as other variables contribute to message transmission in the face of imprecise speech or quiet voice.²³ Conversely, scores may underrate the problem. People with PD can raise their speech performance when concentrating in short bursts when it matters,²⁴ situations which may theoretically include research assessments. Reading single words for an intelligibility test is cognitively relatively undemanding. When people with PD speak in conditions simulating day‐to‐day conversation, speech scores can fall significantly.²⁵ The “self‐perception” ratings reported in this study may be supportive of this theory.

We have shown that intelligibility of speech to everyday listeners is reduced in people with PD compared with matched control speakers, with communication difficulties not dependant on disease severity, motor phenotype or disease duration. We have also demonstrated that people with PD rate their own communication difficulties as a key and important problem. Further research is required to investigate the interactions of intelligibility scores with cognitive and mood status and self‐perceptions of change.

Abbreviations

MMSE - Mini‐Mental State Examination

PD - Parkinson's disease

UPDRS - Unified Parkinson's Disease Rating Scale

Appendix 1

Table A1 lists the sample items from the intelligibility test score sheet

Table A1 Sample items from intelligibility test score sheet.

cub

coop

cup

carp

keep

sheep

cape

heap

cop

hub

cap

hoop

one

fall

what

wash

waltz

wool

watts

was

wad

want

warn

watch

It was a lace meeting

It was a late meeting

It was a grace meeting

It was a race meeting

It was a rate meeting

It was a great meeting

It was a gate meeting

It was a guide meeting

It was a Greece meeting

It was a grade meeting

It was a grey meeting

It was a gay meeting

Dodder

Dosser

Dotter

Topper

Hopper

Robber

Dollar

Docker

Doffer

Stopper

Dobber

Rocker

That girl's body

That girl's fatty

That girl's forty

That girl's ratty

That girl's potty

That girl's Patty

That girl's petty

That girl's dotty

That girl's Betty

That girl's batty

That girl's party

That girl's daddy

Can you cut down the plane please

Can you cut down the steaks please

Can you cut down the place please

Can you cut down the plates please

Can you cut down the seats please

Can you cut down the peas please

Can you cut down the piece please

Can you cut down the pain please

Can you cut down the space please

Can you cut down the pace please

Can you cut down the lace please

Can you cut down the lane please