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. 1987 Jan;169(1):438–441. doi: 10.1128/jb.169.1.438-441.1987

Isolation and characterization of a substitution mutation in the ompR gene of Salmonella typhimurium LT2.

P Liljeström, M Luokkamäki, E T Palva
PMCID: PMC211790  PMID: 3539926

Abstract

The expression of the genes ompC and ompF encoding major outer membrane proteins is dependent on the ompR-envZ operon. Here we describe the isolation and characterization of an ompR mutation, a single-base-pair change, that results in an Arg-to-Cys substitution. When present in multiple copies, the mutant allele conferred a dominant OmpC- OmpF+ phenotype. Furthermore, the mutant allele exhibited allele-specific negative complementation with other ompR mutations. This ability, together with its dominant character, suggested that the OmpR protein is capable of multimerization.

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Selected References

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