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. 1991 Feb 1;173(2):409–415. doi: 10.1084/jem.173.2.409

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

PMCID: PMC2118803  PMID: 1988542

Abstract

Circular DNAs excised by immunoglobulin kappa chain gene rearrangements were cloned and characterized. 16 of 17 clones examined were double recombination products containing a V kappa-J kappa rearrangement (coding joint) as well as the reciprocal element (signal joint) of another V kappa-J kappa rearrangement. These products suggested multiple recombination, primary inversion, and secondary excision. In primary events, 5 of 16 translational reading frames were in-phase. Thus, V kappa gene rearrangement may not be inhibited by the presence of a productively rearranged allele. An unusually large trinucleotide (P) insertion forming a palindrome of 12 nucleotides was also observed in one of the coding joints.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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