Abstract
Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes- resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number of differences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for the phenotypes.
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Selected References
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- Butler L., Guberski D. L., Like A. A. Genetic analysis of the BB/W diabetic rat. Can J Genet Cytol. 1983 Feb;25(1):7–15. doi: 10.1139/g83-002. [DOI] [PubMed] [Google Scholar]
- Chao N. J., Timmerman L., McDevitt H. O., Jacob C. O. Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics. 1989;29(4):231–234. doi: 10.1007/BF00717906. [DOI] [PubMed] [Google Scholar]
- Georgiou H. M., Lagarde A. C., Bellgrau D. T cell dysfunction in the diabetes-prone BB rat. A role for thymic migrants that are not T cell precursors. J Exp Med. 1988 Jan 1;167(1):132–148. doi: 10.1084/jem.167.1.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guberski D. L., Butler L., Kastern W., Like A. A. Genetic studies in inbred BB/Wor rats. Analysis of progeny produced by crossing lymphopenic diabetes-prone rats with nonlymphopenic diabetic rats. Diabetes. 1989 Jul;38(7):887–893. doi: 10.2337/diab.38.7.887. [DOI] [PubMed] [Google Scholar]
- Herold K. C., Kastern W., Markholst H., Lernmark A. Derivation of non-lymphopenic BB rats with an intercross breeding. Autoimmunity. 1989;3(2):83–93. doi: 10.3109/08916938909019957. [DOI] [PubMed] [Google Scholar]
- Holowachuk E. W., Greer M. K. Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats. Diabetes. 1989 Feb;38(2):267–271. doi: 10.2337/diab.38.2.267. [DOI] [PubMed] [Google Scholar]
- Jackson R. A., Buse J. B., Rifai R., Pelletier D., Milford E. L., Carpenter C. B., Eisenbarth G. S., Williams R. M. Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J Exp Med. 1984 Jun 1;159(6):1629–1636. doi: 10.1084/jem.159.6.1629. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kryspin-Sørensen I., Dyrberg T., Kastern W. Genetic heterogeneity in the major histocompatibility complex of various BB rat sublines. Diabetologia. 1986 May;29(5):307–312. doi: 10.1007/BF00452068. [DOI] [PubMed] [Google Scholar]
- Like A. A., Guberski D. L., Butler L. Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic. J Immunol. 1986 May 1;136(9):3254–3258. [PubMed] [Google Scholar]
- Marliss E. B., Nakhooda A. F., Poussier P., Sima A. A. The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia. 1982 Apr;22(4):225–232. doi: 10.1007/BF00281296. [DOI] [PubMed] [Google Scholar]
- Mordes J. P., Desemone J., Rossini A. A. The BB rat. Diabetes Metab Rev. 1987 Jul;3(3):725–750. doi: 10.1002/dmr.5610030307. [DOI] [PubMed] [Google Scholar]