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. 1991 Dec 1;174(6):1661–1664. doi: 10.1084/jem.174.6.1661

Human immunodeficiency virus infection of eosinophils in human bone marrow cultures

PMCID: PMC2119059  PMID: 1744591

Abstract

Normal human bone marrow, cultured in vitro with interleukin 5 to promote eosinophil production and maturation, was inoculated with cell- free isolates of human immunodeficiency virus type 1 (HIV-1). CD4 expression by eosinophil precursors, determined by immunocytochemistry, was found to be greatest early in their maturation with a rapid decline after 28 d in culture. Productive HIV infection of eosinophil precursors was detected 14 d after inoculation, by a combination of immunostaining for HIV-1 p24 and gp41/160 and in situ hybridization for viral RNA, together with assay of culture supernatants for p24 antigen and reverse transcriptase activity. Thus, eosinophils are susceptible to productive HIV-1 infection in vitro and may be an important reservoir for the virus in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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