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. 1993 Jun 2;121(6):1191–1196. doi: 10.1083/jcb.121.6.1191

A new perspective on microtubules and axon growth

PMCID: PMC2119710  PMID: 8509443

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Selected References

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  1. Ahmad F. J., Pienkowski T. P., Baas P. W. Regional differences in microtubule dynamics in the axon. J Neurosci. 1993 Feb;13(2):856–866. doi: 10.1523/JNEUROSCI.13-02-00856.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baas P. W., Ahmad F. J. The plus ends of stable microtubules are the exclusive nucleating structures for microtubules in the axon. J Cell Biol. 1992 Mar;116(5):1231–1241. doi: 10.1083/jcb.116.5.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baas P. W., Ahmad F. J. The transport properties of axonal microtubules establish their polarity orientation. J Cell Biol. 1993 Mar;120(6):1427–1437. doi: 10.1083/jcb.120.6.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baas P. W., Black M. M. Individual microtubules in the axon consist of domains that differ in both composition and stability. J Cell Biol. 1990 Aug;111(2):495–509. doi: 10.1083/jcb.111.2.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Baas P. W., Deitch J. S., Black M. M., Banker G. A. Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8335–8339. doi: 10.1073/pnas.85.21.8335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Baas P. W., Heidemann S. R. Microtubule reassembly from nucleating fragments during the regrowth of amputated neurites. J Cell Biol. 1986 Sep;103(3):917–927. doi: 10.1083/jcb.103.3.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Baas P. W., Joshi H. C. Gamma-tubulin distribution in the neuron: implications for the origins of neuritic microtubules. J Cell Biol. 1992 Oct;119(1):171–178. doi: 10.1083/jcb.119.1.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bamburg J. R., Bray D., Chapman K. Assembly of microtubules at the tip of growing axons. Nature. 1986 Jun 19;321(6072):788–790. doi: 10.1038/321788a0. [DOI] [PubMed] [Google Scholar]
  9. Black M. M., Baas P. W. The basis of polarity in neurons. Trends Neurosci. 1989 Jun;12(6):211–214. doi: 10.1016/0166-2236(89)90124-0. [DOI] [PubMed] [Google Scholar]
  10. Brady S. T. Molecular motors in the nervous system. Neuron. 1991 Oct;7(4):521–533. doi: 10.1016/0896-6273(91)90365-7. [DOI] [PubMed] [Google Scholar]
  11. Bray D., Bunge M. B. Serial analysis of microtubules in cultured rat sensory axons. J Neurocytol. 1981 Aug;10(4):589–605. doi: 10.1007/BF01262592. [DOI] [PubMed] [Google Scholar]
  12. Bray D., Thomas C., Shaw G. Growth cone formation in cultures of sensory neurons. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5226–5229. doi: 10.1073/pnas.75.10.5226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Evans L., Mitchison T., Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr;100(4):1185–1191. doi: 10.1083/jcb.100.4.1185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Fuller M. T., Wilson P. G. Force and counterforce in the mitotic spindle. Cell. 1992 Nov 13;71(4):547–550. doi: 10.1016/0092-8674(92)90587-3. [DOI] [PubMed] [Google Scholar]
  15. Heidemann S. R., Hamborg M. A., Thomas S. J., Song B., Lindley S., Chu D. Spatial organization of axonal microtubules. J Cell Biol. 1984 Oct;99(4 Pt 1):1289–1295. doi: 10.1083/jcb.99.4.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Joshi H. C., Baas P., Chu D. T., Heidemann S. R. The cytoskeleton of neurites after microtubule depolymerization. Exp Cell Res. 1986 Mar;163(1):233–245. doi: 10.1016/0014-4827(86)90576-8. [DOI] [PubMed] [Google Scholar]
  17. Joshi H. C., Palacios M. J., McNamara L., Cleveland D. W. Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature. 1992 Mar 5;356(6364):80–83. doi: 10.1038/356080a0. [DOI] [PubMed] [Google Scholar]
  18. Keith C. H. Slow transport of tubulin in the neurites of differentiated PC12 cells. Science. 1987 Jan 16;235(4786):337–339. doi: 10.1126/science.2432662. [DOI] [PubMed] [Google Scholar]
  19. Kirschner M., Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986 May 9;45(3):329–342. doi: 10.1016/0092-8674(86)90318-1. [DOI] [PubMed] [Google Scholar]
  20. Koonce M. P., Schliwa M. Reactivation of organelle movements along the cytoskeletal framework of a giant freshwater ameba. J Cell Biol. 1986 Aug;103(2):605–612. doi: 10.1083/jcb.103.2.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Lasek R. J., Brady S. T. The axon: a prototype for studying expressional cytoplasm. Cold Spring Harb Symp Quant Biol. 1982;46(Pt 1):113–124. doi: 10.1101/sqb.1982.046.01.015. [DOI] [PubMed] [Google Scholar]
  22. Lasek R. J. Translocation of the neuronal cytoskeleton and axonal locomotion. Philos Trans R Soc Lond B Biol Sci. 1982 Nov 4;299(1095):313–327. doi: 10.1098/rstb.1982.0135. [DOI] [PubMed] [Google Scholar]
  23. Lim S. S., Edson K. J., Letourneau P. C., Borisy G. G. A test of microtubule translocation during neurite elongation. J Cell Biol. 1990 Jul;111(1):123–130. doi: 10.1083/jcb.111.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lim S. S., Sammak P. J., Borisy G. G. Progressive and spatially differentiated stability of microtubules in developing neuronal cells. J Cell Biol. 1989 Jul;109(1):253–263. doi: 10.1083/jcb.109.1.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Mandelkow E. M., Mandelkow E. Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly. J Mol Biol. 1985 Jan 5;181(1):123–135. doi: 10.1016/0022-2836(85)90330-4. [DOI] [PubMed] [Google Scholar]
  26. Mogensen M. M., Tucker J. B., Stebbings H. Microtubule polarities indicate that nucleation and capture of microtubules occurs at cell surfaces in Drosophila. J Cell Biol. 1989 Apr;108(4):1445–1452. doi: 10.1083/jcb.108.4.1445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Morris J. R., Lasek R. J. Monomer-polymer equilibria in the axon: direct measurement of tubulin and actin as polymer and monomer in axoplasm. J Cell Biol. 1984 Jun;98(6):2064–2076. doi: 10.1083/jcb.98.6.2064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Nicklas R. B., Lee G. M., Rieder C. L., Rupp G. Mechanically cut mitotic spindles: clean cuts and stable microtubules. J Cell Sci. 1989 Nov;94(Pt 3):415–423. doi: 10.1242/jcs.94.3.415. [DOI] [PubMed] [Google Scholar]
  29. Oakley C. E., Oakley B. R. Identification of gamma-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans. Nature. 1989 Apr 20;338(6217):662–664. doi: 10.1038/338662a0. [DOI] [PubMed] [Google Scholar]
  30. Okabe S., Hirokawa N. Differential behavior of photoactivated microtubules in growing axons of mouse and frog neurons. J Cell Biol. 1992 Apr;117(1):105–120. doi: 10.1083/jcb.117.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Okabe S., Hirokawa N. Do photobleached fluorescent microtubules move?: re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon. J Cell Biol. 1993 Mar;120(5):1177–1186. doi: 10.1083/jcb.120.5.1177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Okabe S., Hirokawa N. Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells. J Cell Biol. 1988 Aug;107(2):651–664. doi: 10.1083/jcb.107.2.651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Okabe S., Hirokawa N. Turnover of fluorescently labelled tubulin and actin in the axon. Nature. 1990 Feb 1;343(6257):479–482. doi: 10.1038/343479a0. [DOI] [PubMed] [Google Scholar]
  34. Reinsch S. S., Mitchison T. J., Kirschner M. Microtubule polymer assembly and transport during axonal elongation. J Cell Biol. 1991 Oct;115(2):365–379. doi: 10.1083/jcb.115.2.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Sanders M. A., Salisbury J. L. Centrin-mediated microtubule severing during flagellar excision in Chlamydomonas reinhardtii. J Cell Biol. 1989 May;108(5):1751–1760. doi: 10.1083/jcb.108.5.1751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Satir P. Mechanisms and controls of microtubule sliding in cilia. Symp Soc Exp Biol. 1982;35:179–201. [PubMed] [Google Scholar]
  37. Tennyson V. M. Electron microscopic study of the developing neuroblast of the dorsal root ganglion of the rabbit embryo. J Comp Neurol. 1965 Jun;124(3):267–317. doi: 10.1002/cne.901240302. [DOI] [PubMed] [Google Scholar]
  38. Tilney L. G., Bryan J., Bush D. J., Fujiwara K., Mooseker M. S., Murphy D. B., Snyder D. H. Microtubules: evidence for 13 protofilaments. J Cell Biol. 1973 Nov;59(2 Pt 1):267–275. doi: 10.1083/jcb.59.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Vale R. D., Schnapp B. J., Reese T. S., Sheetz M. P. Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon. Cell. 1985 Mar;40(3):559–569. doi: 10.1016/0092-8674(85)90204-1. [DOI] [PubMed] [Google Scholar]
  40. Vale R. D. Severing of stable microtubules by a mitotically activated protein in Xenopus egg extracts. Cell. 1991 Feb 22;64(4):827–839. doi: 10.1016/0092-8674(91)90511-v. [DOI] [PubMed] [Google Scholar]
  41. Vigers G. P., Coue M., McIntosh J. R. Fluorescent microtubules break up under illumination. J Cell Biol. 1988 Sep;107(3):1011–1024. doi: 10.1083/jcb.107.3.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. White L. A., Baas P. W., Heidemann S. R. Microtubule stability in severed axons. J Neurocytol. 1987 Dec;16(6):775–784. doi: 10.1007/BF01611985. [DOI] [PubMed] [Google Scholar]

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